摘要
目的 :探讨黑质内注射脂多糖对黑质纹状体系统单胺类递质的影响。方法 :将 2 0只SD大鼠随机分成A、B、C 3组和对照组D ,取各组大鼠纹状体和黑质组织 ,采用高压液相色谱 电化学法 (HPLC ECD)检测该部位的单胺类递质含量。结果 :A、B、C 3组纹状体、黑质部位多巴胺及其代谢产物含量明显并持续降低 ,较D组均有显著性差异 ,但纹状体、黑质部位 5 羟色胺含量仅有一过性变化。结论 :黑质内注射脂多糖能使纹状体。
Aim:To investigate the effect of intranigral injection of the immunostimulant lipoplysaccharide(LPS) on monoamine transmitters in the nigrostriatal system.Methods:Twenty rats were randomly divided into 4 groups:group A(14 days after LPS injection),group B(21 days after LPS injection),group C(28 days after LPS injection)and group D(14 days after PBS injection).Animals were decapitated at different time and the monoamine transmitters in the striatum and substantia nigra were measured by high performance liquid chromatography with electrical detection(HPLC ECD).Results:In group A,B and C,the levels of dopamine and its metabolite(DOPAC) in the striatum and substantia nigra were significantly decreased,compared with group D.The content of serotonin in the striatum and substantia nigra showed transient change.Conclusion:Intranigral injection of LPS can significantly reduce the dopamine transmitter in the nigrostriatal system
出处
《中国临床神经科学》
2002年第2期109-111,共3页
Chinese Journal of Clinical Neurosciences
基金
国家重点基础研究规划"脑功能和脑重大疾病的基础研究"项目 (G19990 54 0 0 8)资助项目
上海市卫生系统跨世纪优秀学科带头人培养计划资助项目 ( 97BR0 0 1)
上海市科委青年科技"启明星后"计划资助项目 ( 97QMB14 10 )。
