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肿瘤基因疫苗的研究进展 被引量:1

Advances in tumor gene vaccines
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摘要 肿瘤基因疫苗是肿瘤主动特异性免疫治疗的核心。本文就肿瘤基因疫苗的构建、靶基因的选择以及免疫效应等方面的研究进展作一综述。 Tumor gene vaccines play a very important vole in the active specific immunotherapy. This article briefly reviews how to construct tumor gene vaccines, choose the target gene and induce immune response.
作者 方路 吴玉章
出处 《免疫学杂志》 CAS CSCD 北大核心 2002年第B06期124-127,共4页 Immunological Journal
关键词 肿瘤基因疫苗 研究进展 免疫应答 主动特异性免疫治疗 tumor gene vaccines immune response
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  • 1Blezinger P,Nature Biotechnol,1999年,17卷,343页
  • 2Chen Y,Cancer Res,1998年,58卷,1965页
  • 3King C A,Nature Med,1998年,4卷,1281页

同被引文献8

  • 1Mendiratta SK, Thai G, Eslahi NK, et al. Therapeutic tumor immunity induced by polyimmunization with melanoma antigens gp100 and TRP-2[J]. Cancer Res,2001, 61(3):859-863.
  • 2Strobl H, Knapp W. TGF-beta1 regulation of dendritic cells[J]. Microbes Infect,1999,1(15):1 283-1 290.
  • 3Lin CM, Wang FH, Lee PK. Activated human CD4+ T cells induced by dendritic cell stimulation are most sensitive to transforming growth factor-beta: implications for dendritic cell immunization against cancer[J]. Clin Immunol,2002, 102(1):96-105.
  • 4Kobie JJ, Wu RS, Kurt RA, et al. Transforming growth factor beta inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines[J]. Cancer Res,2003, 63(8):1 860-1 864.
  • 5Kao JY, Gong Y, Chen CM, et al. Tumor-derived TGF-beta reduces the efficacy of dendritic cell/tumor fusion vaccine[J]. J Immunol,2003,170(7): 3 806-3 811.
  • 6Steitz J, Bruck J, Steinbrink K, et al. Genetic immunization of mice with human tyrosinase-related protein 2: implications for the immunotherapy of melanoma[J]. Int J Cancer,2000,86(1):89-94.
  • 7Gorelik L, Flavell RA. Immune-mediated eradication of tumors through the blockage of transforming growth factor-β signaling in T cells[J]. Nat Med, 2001,7(10): 1 118- 1 122.
  • 8邹强,郑萍,杨桦,郭波,万瑛,孟祥贵.小鼠补体C3d分子cDNA的克隆及鉴定[J].免疫学杂志,2003,19(3):227-229. 被引量:7

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