摘要
目的将活细胞种植于可生物降解的瓣膜支架上,制造出一种组织相容性好,不需抗凝,具有修复能力,且支持患者终生的理想心脏瓣膜。方法胶原膜和聚乙醇酸/聚乳酸共聚物(PGLA)在皮下包埋和种植细胞生长做对照实验。结果胶原膜皮下包埋8周仍保持膜状结构,8～12周完全降解,且生物相容性优于聚乙醇酸/聚乳酸共聚物(PGLA)。结论胶原膜适于组织工程心脏瓣膜支架材料的应用。
Objective Tissue engineering heart valve is a n ew approach in which tissue engineering techniques are being developed t o transplant active cells onto biodeg radable scaffolds to ultimately form new functional heart valve.The seeded cells proliferate,organize,an d produce cellular and extracellular matrix.During this matrix formatio n,the starter scaffold is degraded,absorbed,or metabolized.This type of heart valve with the optimal abili ties to biocompatibility,anticoagulation and longevity.Method Contrast analyze the seeded cells growth and hypodermic implantation of collagenous film and PGLA.Results Collagenous film retained the membr anous structure after 8weeks' hypodermic implantation,complete degradation of the polymer occurred by 8～12weeks.The biocompatibility was better than that of PGLA.Conclusion Collagenous film can be used to fabricate a three-dimensional,biodegra dable tissue engineering heart valv e scaffold.
出处
《中国临床康复》
CSCD
2002年第12期1751-1752,共2页
Chinese Journal of Clinical Rehabilitation
基金
国家自然科学基金资助项目(39970733)
关键词
胶原膜
聚乙醇酸
聚乳酸
组织工程
心脏瓣膜支架材料
collagenous film
polymer of polyglycolic acid and polylactic acid(PGLA)
tissue engineering
heart valve
