摘要
目的 探讨胃食管反流病 (GERD)与幽门螺杆菌 (H .pylori)感染的关系。方法 将内镜诊断的 60 4例GERD患者 ,依据H .pylori检测结果分为阳性组和阴性组 ,按Tytagat分级进行严重度比较 ;H .pylori阳性组H .pylori根除后与H .pylori阴性组一年复发率的比较。结果 60 4例GERD患者中Ⅲ～Ⅴ级的中重度检出率 :H .pylori阳性组为 3 1.2 % (114 3 66) ,H .pylori阴性组为 3 8.7% (92 2 3 8)。两组比较差异有显著性 (P <0 .0 5 )。H .pylori阳性组GERD患者H .pylori根除后 1年复发率为 3 1.1% (5 1 164 ) ,H .pylori阴性组的CEDR患者 1年复发率为 15 .6% (16 10 2 ) ,两组比较差异有显著性 (P <0 .0 5 )。结论 H .pylori阴性者GERD病变程度较重 ,H .pylori阳性的GERD患者H .pylori根除后 1年的复发率较高 ,显示H .pylori感染可能对GERD发病起保护作用。
Objective To investigate the relationship between gastrophageal reflux diseases (GERD) and the helicobacter pylori (H.pylori) infection.Methods 604 patients with GERD diagnosed by endosecopy were divided into two groups accoding to the results of H.pylori test,one was positive group and the other was negetive group.The severity was compared accoding to the Tytagat level;the recurrent rate was compared as well.Results Among 604 patients,the detection rate of 3～5 degree was 31.2% (114/366) in positive group and 38.7% (51/164) in negetive group.There was a significant difference between the two groups (P<0.05).The recurrent rate was 31.1% (51/164) in positive group one year after H.pylori was eradicated,and 15.6% (16/102) in negetive group,there was a significant difference between the two groups (P<0.05).Conclusion The severity of the disease in negetive group is more serious,and the recurrent rate in positive group one year after eradication of H.pylori is higher,which suggests that H.pylori infection may play an important role in protecting from GERD incidence.
出处
《河北医药》
CAS
2002年第6期463-464,共2页
Hebei Medical Journal
