摘要
目的探讨氟作业工人有关生化指标的相关关系。方法选择某铝厂男性电解工及同企业男性机械工各50名进行尿F-、血F-,血清降钙素(CT)、甲状旁腺素(PTH)、碱性磷酸酶(AKP)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)、IgG、IgA、IgM、Cu2+、Zn2+、Ca2+、Mg2+、Se2+水平的测定。结果与对照组相比,暴露组尿F-、血F、CT、PTH、AKP、GSH-Px的差异有显著性(P<0.01);相关分析显示,暴露组尿F-与CAT(r=0.3133,P<0.05)、CT与PTH(r=0.5173,P<0.01)、微量元素Se2+与CAT(r=0.4354,P<0.05)呈正相关,血F-与GSH-Px(r=-0.5202,P<0.01)呈负相关,血中Cu2+、Zn2+、Ca2+、Mg2+间有一定的正相关关系。结论(1)过量氟可影响CT、PTH的分泌;(2)AKP、GSH-Px的改变可作为氟作业工人的健康监护指标;(3)生化指标的相关性研究对探讨工业性氟病机制及早期防治有积极的作用。
Objective To explore the correlation among some biochemical indexes in the fluoride workers.Meth ods The activities of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),catalase(CAT),alka-line phosphatase(AKP)and the level of calcitonin(CT),parathyroid hormone(PTH),IgG,IgA,IgM,Cu 2+ ,Zn 2+ ,Ca 2+ ,Mg 2+ and Se 2+ ,F - in serum and in urine were measured in fifty male fluoride workers and fifty controls.Re sults The levels of F - ,CT,PTH,AKP and GSH-Px in serum and F - in urine in exposed group were significantly differ-ent from that in control group.Correlation analysis indicated that F - in urine and CAT(r=0.3133,P<0.05),CT and PTH(r=0.5173,P<0.01),Se 2+ and CAT(r=0.4354,P<0.05)were positively correlated.There were sig-nificantly negative correlation between F - in serum and GSH-Px(r=-0.5202,P<0.01)and positive correlation among Cu 2+ ,Zn 2+ ,Ca 2+ and Mg 2+ in serum.Conclu sion(1)Excess of fluoride may affect secretion of calcium ad-justing hormone(CT,PTH);(2)Changes of AKP and GSH-Px may be regarded as health monitoring indexes;(3)The correlation of biochemical indexes plays an important role in studying the mechanism and the early prevention and treatment of industrial fluorosis.[
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
北大核心
2002年第3期192-194,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
