摘要
目的 :探讨低分子量肝素 (LMWH)对重症胰腺炎 (SAP)患者的疗效。方法 :回顾对比分析LMWH治疗组 31例和对照组 4 8例的疗效情况。结果 :治疗组 31例中治愈 2 8例 (占 90 .3% ) ,死亡 3例 (占 9.7% )。对照组 4 8例中治愈 35例 (占 72 .9% ) ,死亡 13例 (占 2 7.1% )。治疗组平均住院时间 (2 9± 7)d ,较对照组平均住院时间 (41± 9)d明显减少 (P <0 .0 1)。治疗组的并发症发生率 (32 .3% ,10例 18例次 )明显偏低于对照组 (6 2 .5 % ,30例 5 9例次 ) (P <0 .0 1)。结论 :LMWH能改善胰腺微循环、减轻缺血 再灌注损伤 。
Objective:To investigate the effects of low molecular weight(LMWH) on severe acute pancreatitis(SAP).Methods:Retrospective analysis was made on the clinical features and therapeutic effect of the control group in 48 cases and LMWH treatment group in 31 cases.Results:28(90.3%) out of 31 cases were cured and 3(9.7%) died in treatment group;35(72.9%) out of 48 cases were cured and 15(27.1%) died in control group. The average hospitalization time of treatment group(29±9)d was significantly shorter than that of control group(41±9)d,P<0.01. The complications occurred in treatment group(32.3%,10 patients 18 times) were significantly lower than the control group(62.5%,30 patients 59 times)(P<0.01).Conclusion:LMWH can improve pancreatic microcirculation and decrease the ischemia reperflusion injury of the pancrease. So LMWH as a adjunctive therapeutic method can improve the therapeatic effect of SAP.
出处
《肝胆胰外科杂志》
CAS
2002年第2期76-77,79,共3页
Journal of Hepatopancreatobiliary Surgery
关键词
肝素
低分子量
胰腺炎
对比研究
治疗
heparin,low molecular weight
pancreatitis
comparative study
