摘要
目的 探讨非小细胞肺癌 (NSCLC)组织中葡萄糖转运蛋白 1(GLUT1)的表达及其与1 8F 2 脱氧葡萄糖 (FDG)摄取之间的关系。方法 术前对 2 4例NSCLC患者进行1 8FDG PET检查。采用免疫组织化学方法检测肺癌组织及相应正常肺组织中GLUT1的表达 ,并使用计算机图像分析技术对肺癌组织中GLUT1表达水平进行了定量分析 ,并与术前FDG PET检查所得标准化摄取值 (SUV)进行相关性分析。结果 2 4例NSCLC标本GLUT1蛋白染色全部阳性。相应正常肺组织中 ,正常支气管上皮和肺泡上皮细胞均无GLUT1蛋白染色。肺癌组织中GLUT1平均光密度值与SUV值之间呈直线相关 (r =0 .86,P <0 .0 5 )。结论 GLUT1蛋白在NSCLC肿瘤组织中广泛表达 。
Objective To investigate the expression of facilitative glucose transporter 1 (GLUT1) and its relationship with uptake of 18 fluoro 2 deoxyglucose (FDG) in non small cell lung cancer (NSCLC). Methods Twenty four patients with NSCLC were evaluated with 18 FDG PET examination before operation. The expression of GLUT1 was detected immunohistochemically in lung cancer and normal lung tissues, and the intensity of GLUT1 in lung cancer was assessed by computer image analysis. Correlation analysis was carried out between expression level of GLUT1 and value of SUV obtained from preoperative FDG PET. Results Expression of GLUT1 protein was positive in 24 cases of NSCLC samples, but negative in corresponding normal tissues. A highly significant linear correlation was found between GLUT1 expression and SUV value (r= 0.86, P<0.05). Conclusion GLUT1 expression is quite general in NSCLC tissues, and it may play an important role in the glucose uptake of NSCLC cells.
出处
《中国肺癌杂志》
CAS
2002年第3期174-176,共3页
Chinese Journal of Lung Cancer
