摘要
ＤＮＡ甲基化在基因调节和动物发育中起着重要作用。负责ＤＮＡ甲基化作用的酶称为ＤＮＡ甲基转移酶(Ｄｎｍｔｓ)。到目前为止,在哺乳动物细胞中已经鉴定了三种ＤＮＡ甲基转移酶基因家族,即Ｄｎｍｔ１、Ｄｎｍｔ２和Ｄｎｍｔ３。鉴定和研究ＤＮＡ甲基转移酶对阐明ＤＮＡ甲基化机制起着关键的作用。
DNA methylation plays an important role in gene regulation and animal development. The enzymes responsible for DNA methylation are called the DNA methyltransferases (Dnmts). Up to now, three distinct families of DNA methyltranferase genes, termed Dnmt1, Dnmt2 and Dnmt3, have been identified in mammalian cells. It is crucial to identify and study the DNA methyltransferases to elucidate the DNA methylation mechanism.
出处
《生命科学》
CSCD
2002年第3期141-143,共3页
Chinese Bulletin of Life Sciences
