摘要
目的快速制备水溶性壳聚糖。方法利用微波辐射 ,用过氧化氢作氧化剂 ,非均相降解高分子量壳聚糖。设计了正交试验法 ,得到最优化反应条件。结果最优反应条件为 5 %过氧化氢、5 %壳聚糖 ,微波辐射功率约40 0W ,辐射 3min ,所得水溶性壳聚糖分子量为 1 .1× 1 0 4 D ,收率可达 60 %。结论微波法制备低聚壳聚糖效果理想 。
PurposeTo prepare water soluble chitosan rapidly and easily.MethodsA water soluble chitosan was prepared using directly oxidative degradation by H 2O 2 under microwave radiation. The process was investigated by orthogonal experimental design.ResultsIt was shown that the best conditions were 5% H 2O 2, 5% chitosan, microwave power about 400 W, and microwave radiation time 3 min, the molecular weight of water soluble chitosan was about 1.1×10 4,the yield was 60%.ConclusionThe effect of preparation of water soluble chitosan by oxidation degradation under microwave radiation is ideal. Microwave radiation may be possibly used in other field of chitosan chemical modification.
出处
《中国生化药物杂志》
CAS
CSCD
2002年第3期132-133,共2页
Chinese Journal of Biochemical Pharmaceutics
关键词
微波辐射
壳聚糖
水溶性壳聚糖
氧化降解
microwave radiation
chitosan
water soluble chitosan
oxidation degradation
