摘要
本文报道了7个2-取代-6-氧代-10-[2-(N-取代)氨甲酰基]乙基-6,7,8,9-四氢吡啶并[1,2-a]吲哚类化合物的合成。初步药理试验表明,设计合成的化合物均有一定程度的扩张脑血管作用,其中化合物Ⅰ_7的作用最为明显。构效关系显示酰胺结构中二乙氨基乙胺的作用强于二甲氨基乙胺。
Aseries of 2 - substituted-6-oxo -10 -[2 - (N- substituted)carbamoyl] ethyl -6,7,8,9 - tetrahydro - pyrido[1,2 -a] indole compounds were synthesized for studying the relation between structures and cerebrovascular activities. The structures of compounds synthesized were confirmed by means of ~1HNMR, M S, IR, UV and elemental analysis.Preliminary pharmacological experiments showed that all these new compounds were effective for cerebral vasodilation. Compound I_7 was the best of all. The β- diethylaminoethylamine moiety seems to be better than β- dimethylaminoethylamine.
出处
《药学学报》
CAS
CSCD
北大核心
1991年第4期255-260,共6页
Acta Pharmaceutica Sinica
