摘要
以硝苯吡啶为代表的1,4-二氢吡啶类化合物是一种有效的钙拮抗剂,广泛用于治疗心绞痛、室上心律失常、高血压和外周血管性疾病,同时也用于进行放射配基结合实验,以深入了解人体中生理钙及钙通道的性质和功能。目前已用于临床的这类钙拮抗剂主要有硝苯吡啶、间硝苯吡啶和硝苯苄啶等。
Calcium antagonists are drugs that selectively block potential dependent Ca^(2+) -channel and inhibit Ca^(2+) withdrawal on cell membrane .These drugs are used to treat cardiovascular or cephalovascular diseases. 1,4- Dihydropyridine derivatives in comparison with other drugs, have higher potency and selectivity on Ca^(2+)- antagonists.They are vasodilators and hypotensives. In this paper,eleven new dihydropyridine derivatives were prepared with the method of Hantzsch and were characterized on the basis of elemental analysis, intrared spectroscopy (IR) and proton naclear magnetic resonance (~1HNMR).The solubility in water,stability to heat and Ca^(2+)-antagonistic activity of the new compounds were reported.
出处
《药学学报》
CAS
CSCD
北大核心
1991年第5期375-378,共4页
Acta Pharmaceutica Sinica
关键词
二氢吡啶
二羧酸酯类
化合物
合成
Dihydropyridine compounds
Hantzxch synthesis
Calcium antagonists
