摘要
目的 :调查 1998— 2 0 0 0年伤寒、副伤寒和非伤寒沙门菌耐药性的变迁。方法 :纸片扩散法 (K B法 ) ,依照美国临床实验室标准化委员会制定的 2 0 0 0年版的标准。结果 :1.1998— 2 0 0 0年伤寒和副伤寒沙门菌 2 37株 (其中伤寒沙门菌 191株 ,甲、乙、丙副伤寒沙门菌 46株 )对临床常用抗菌药的耐药性变化不大 ;而 12 2株非伤寒沙门菌则增长较快 ,其中对氨苄西林的耐药率从 1998年的 2 6 .6 %增加到 2 0 0 0年的 46 .3%,复方磺胺甲唑从 2 0 .0 %到 5 9.3%,环丙沙星从 10 .0 %到 2 9.6 %。2 0 0 0年氯霉素和四环素的耐药率分别为 31.5 %和 5 0 .0 %。 2 .在非伤寒沙门菌分离株中 ,肠炎沙门菌和鼠伤寒沙门菌为主要血清型。 3.此次分析中发现 3株多重耐药谱为ACTStCp的鼠伤寒沙门菌。 结论 :除复方磺胺甲唑外 ,伤寒、副伤寒沙门菌对临床常用抗菌药仍很敏感。非伤寒沙门菌对临床常用抗菌药耐药率逐渐增加 ,加强其耐药性监测是非常必要的。
Objective: To investigate the resistance trend of S. typhi, S. paratyphi and nontyphoidal salmonella organisms collected from 1998 to 2000 to antimicrobial agents commonly used in clinical setting. Methods:Disk diffusion test (K-B method) was used. Results were assessed according to the criteria of the National Committee of Clinical Laboratory Standards (NCCLS). Results: 1.237 clinical isolates of S. typhi (191) and S. paratyphi A, B, C(46), as well as 122 strains of nontyphoidal salmonella species were collected. The resistance rates of S. typhi and S. paratyphi increased slightly. On the contrary, resistance of nontyphoidal salmonella species increased markedly from 1998 to 2000. The resistance rate of ampicillin increased form 26.6% in 1998 to 46.3% in 2000; TMP/SMZ from 20.0% to 59.3%; ciprofloxacin from 10.0% to 29.6%. The resistance rates of chloramphenicol and tetracycline were 31.5% and 50.0% respectively in 2000. 2. S. enteritidis and S. typhimurium were the major serotypes in nontyphoidal salmonella species. 3. Three multi-resistant isolates with ACTStCp resistant pattern were identified. Conclusions: S. typhi and S. paratyphi were generally susceptible to most commonly used antimicrobial agents except SMZ/TMP. The resistance of nontyphoidal salmonella species is increasing. It is important to monitor the resistance of these microorganisms.
出处
《中国抗感染化疗杂志》
2002年第2期84-86,共3页
Chinese Journal of Infection and Chemotherapy
