摘要
目的 :探讨充血性心力衰竭 (CHF)患者血清可溶性细胞间粘附分子 - 1(s ICAM- 1)的水平与 CHF患者心功能状态的关系。方法 :采用酶联免疫吸附法 (EL ISA)检测 84例 CHF患者 s ICAM- 1水平并与 30例健康人作对照 ,通过彩色多普勒超声心动图测定 CHF患者左室射血分数 (L VEF值 )。结果 :1CHF患者 s ICAM- 1水平 (5 88± 15 2μg· L- 1 )较对照组 (16 7± 35μg· L- 1 )明显升高 ,有显著性差异 (P<0 .0 1)。 2 s ICAM- 1水平随着心功能不全的加重而升高 ,心功能 级患者高于心功能 , 级患者 (P<0 .0 5 ) ,3L VEF值和 s ICAM- 1水平 ,两者呈显著的负相关(r=- 0 .5 5 ,P<0 .0 1)。结论 :s ICAM- 1在 CHF的发病机制中起重要作用 ,s ICAM- 1水平可能是
AIM: To investigate the serum concentration of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with congestive heart failure(CHF)and the relationship between sICAM-1 and their cardiac function. METHODS: The serum level of sICAM-1 was determined with enzyme-linked immunosorbent assay in 84 patients with CHF and 30 healthy individuals(control group). Left ventricular ejection fraction (LVEF) in patients with CHF was measured by colour Dopper echocardiography. RESULTS: The serum levels of sICAM-1 in patients with CHF were significantly higher than those in controls(P<0.01). The serum levels of sICAM-1 have significant increased with the decrease of heart function. The serum levels of sICAM-1 in class Ⅳ patients with CHF were higher than those in class Ⅱand Ⅲ (P<0.05). Serum levels of sICAM-1 negatively correlated to LVEF (r=-0.55, P<0.01). CONCLUSION: sICAM-1 plays an important role in the pathogenesis of CHF. The serum level of sICAM-1 may be important parameter for heart function degree determination and therapy effect observation in patients with CHF.
出处
《心脏杂志》
CAS
2002年第3期245-246,249,共3页
Chinese Heart Journal
关键词
充血性心力衰竭
细胞粘附分子
检测
heart failure, congestive
soluble intercellular adhesion molecule-1
