摘要
目的 :研究缓释阿维菌素明胶微球 (AVM GMS)的制备及其体外释放特性。方法 :采用乳化缩聚法以生物可降解材料明胶为囊材制备AVM GMS ,通过均匀实验设计法得到优化的处方和制备工艺。通过体外释药研究以累计释药百分率进行不同模型拟合 ,以说明AVM GMS的缓释作用。结果 :按优选处方和工艺制备的AVM GMS ,粒径在 1 0～ 2 0 0 μm之间 ,包封率为 68.6 %～ 74.1 %。体外释药规律符合Higuchi方程 ,AVM GMS的t1 2 是AVM原料药的 6 .6倍。结论 :AVM GMS具有明显的缓释作用。
Objective:To prepare a sustained release avermectins gelatin microspheres(AVM GMS) and study its in vitro release characteristics.Methods:AVM GMS was prepared from the biodegradable gelatin by emulsion polymerization,and the optimum formulation and preparation technical process was afforded by the uniform test.The release profile of AVM GMS was shown from the accumulative drug release amount in vitro .Results:The experiment conditions were optimized, the mean volume diameter obtained was 10～200μm and encapsulation rate was 68.6%～74.1%.The profile could be described by Higuchi equation.The release t 1/2 of AVM GMS was about 6.6 times as much as that of original AVM.Conclusion:AVM GMS had obviously sustained effect. [
出处
《中国新药杂志》
CAS
CSCD
北大核心
2002年第6期462-464,共3页
Chinese Journal of New Drugs
基金
新疆维吾尔自治区科学与技术开发计划项目 ( 990 10 10 0 6 )
关键词
阿维菌素
明胶微球
缓释剂
体外释药
avermectins
gelatin microsphere
sustained release system
in vitro release
