摘要
目的 :合成 3 氯 2 ,4,5 三氟苯甲酸。方法 :以 3 ,4,5 ,6 四氟苯二甲酸为起始原料 ,经酯化、氨化、重氮化和桑德迈耳反应制得 3 氯 2 ,4,5 三氟苯甲酸。结果 :酯化时使用发烟硫酸 ;重氮化和桑德迈耳反应时溶剂由水改为水和二氯乙烷 ,使产率增加 ,质量提高。结论 :该合成路线条件温和 ,操作简单 ,收率提高到 61 .8%。
Objective:To synthesize 3 chloro 2,4,5 trifluorobenzoic acid.Methods:The 3 chloro 2,4,5 trifluorobenzoic acid was prepared by esterification,aminogenesis,diazotisation and Sandmeyer reaction of 3,4,5,6 tetrafluorophthalic acid.Results:In the esterification step,fuming sulfuric acid was used;for increased yield and quality,water was substituted by water and dichloroethane as solvent in the process of diazotisation and Sandmeyer reaction.Conclusion:This synthetic process is mild,convenient,simple and gives good yield to 61.8%. [
出处
《中国新药杂志》
CAS
CSCD
北大核心
2002年第6期468-469,共2页
Chinese Journal of New Drugs
