摘要
目的 探讨心脏移植患者合适的免疫抑制剂使用方法。方法 监测 3例行心脏原位移植术后患者的环孢素A全血谷浓度和免疫抑制剂的不良反应。结果 3例患者至今存活 ,生活质量良好。术前术后不同时期对免疫抑制剂使用有不同要求。结论 监测免疫抑制剂使用情况有利于减少急性排斥发生和减低肝肾毒性等不良反应 。
OBJECTIVE: To explore the proper usage of immunosuppression after orthotopic heart transplantation. METHODS: Trough level of blood cyclosporine A was determined by fluorescent polarization immune assay (FPIA) and the side effects of the anti-rejection drug were monitored. RESULTS: Three patients survived with good quality of life. Different concentrations of blood cyclosporine A were pursued at different periods of post transplantation. CONCLUSION: Clinical survey is helpful to prevent the acute rejection and decrease the drug toxicity to the liver and kidney. It is necessary to adjust the dosage of immunosuppression according to the clinic situation.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2002年第7期546-549,共4页
Chinese Pharmaceutical Journal
关键词
原位心脏移植
免疫抑制
环孢素A
免疫排斥反应
Assays
Biological organs
Blood
Patient monitoring
Polarization
Toxicity
Transplants
