摘要
目的 :探讨氯沙坦对原发性高血压病 (EH)患者血管内皮功能的影响。方法 :用高分辨率超声分别检测2 1例用氯沙坦 (5 0mg·d 1 × 12周 )治疗前后的EH患者的肱动脉流量介导的舒张活性 (FMD)和硝酸甘油介导的舒张活性(NTG MD) ,同时取 2 0例正常健康者和 18例经氢氯噻嗪 (12 .5mg ,bid× 12周 )及 或美托洛尔 (2 5～ 5 0mg ,bid× 12周 )治疗的EH患者作对照组 ,并比较分析。结果 :两组EH患者治疗前较正常健康者其FMD呈显著降低 [(7.2 3± 2 .2 7) %和(7.3 6± 2 .0 8) %,vs(11.79± 3 .0 6) %,P <0 .0 1] ,经氯沙坦治疗后FMD呈显著升高 [(7.3 6± 2 .0 8) %,vs(10 .5 3± 2 .70 ) %,P <0 .0 1] ,而对照治疗组治疗后FMD则差异无显著性 (P >0 .0 5 )。NTG MD正常健康组与EH组比较差异无显著性 (P >0 .0 5 ) ,同时两组EH组在治疗前后NTG MD差异亦无显著性 (P >0 .0 5 )。结论 :EH患者存在着显著的血管内皮功能障碍 。
Objective:To explore the effects of losartan on endothelial function in patients with hypertension. Methods:The brachial artery flow mediated dilation (FMD) and Nitroglycerin mediated dilation (NTG MD) were observed in 21 cases (treatment group) with primary hypertension using the high resolution ultrasonography before and after treatment with losartan (50 mg·d 1 ×12 w). Meanwhile, 20 healthy subjects and 18 patients with primary hypertension treated with hydrochorothiazide (12.5 mg, bid×12w) or betaloc (25～50 mg, bid×12 w) were recruited and served as two groups of control. Results:FMD in the two groups of hypertensive patients before treatment were significantly lower than that of the normal subjects(7.23%±2.27% and 7.36%±2.08% versus 11.79% ±3.06%, P <0.01). After 12 weeks of treatment, comparing with that before the treatment, FMD in those treated with losartan was significantly increased (10.53%±2.70%, P <0.01), but FMD in those treated with hydrochorothiazide or betaloc did not changed significantly. NTG MD was not significantly different between the treatment group and the two control groups or between the two control groups. Conclusion:Remarkable dysfunction of vascular endothelium could be observed in patients with primary hypertension, which can be effectively improved by treatment with losartan.
出处
《医药导报》
CAS
2002年第7期424-426,共3页
Herald of Medicine
