摘要
目的 探讨QCT骨密度测量与椎体骨力学强度的相关性 ,以明确QCT预测椎体压缩性骨折的可行性。方法 ①对 3 2个椎体 (T7～L4〕进行了三种方法的QCT骨密度测量 (椎体中部 5mm测量 ;椎体中部 10mm测量 ;椎体 5mm层厚容积测量〕。②对 3 2个椎体做了单轴压缩负荷试验并计算椎体压缩强度。③对三种QCT测量所得BMD值与椎体压强做了相关性分析。结果 三种QCT测量法所得BMD值与椎体压强均成正比 ,相关性显著 (P <0 .0 1)。椎体中部 10mm层厚测量与椎体压强相关性最显著 (r =0 .777) ,椎体压强随BMD的增加有递增趋势 ,椎体压强与BMD之间存在平方回归关系 ,其最佳方程为y =2 2 2 .15 1-2 .3 5 4x + 0 .0 17x2 。结论 QCT测量作为一种非侵入性方法以其高度的敏感性和准确性可以估计椎体的压强从而预测骨折的危险性 ,其中以椎体中部 10mm测量最敏感 。
Purpose To evaluate the correlation between the BMD and bone strength in vertebrae,so as to define the possibility of QCT in predicting the fracture of vertebrae. Methods ①Thirty two vertebrae (T 7-L 4) were measured with three strategies using QCT (a single 5mm midplane section; a single 10mm midplane section and 5mm contiguous section volumetric scanning). ②The mechanical test of uniaxial compressive loads was performed and the vertebral compressive strength (VCS) was calculated. ③The correlation between VCS and the BMD yielded from three separate QCT measurement was analyzed. Results VCS was noted to increase with the increasing of BMD, the BMDs of three separate QCT measurement were correlated at a high level of significance ( P <0.01) and the BMD of 10mm midplane section measurement was correlated highest with the VCS ( r =0.777). The VCS was related to the square of the BMD with the equation: y= 222.151 -2.354x+0.017x 2. Conclusion QCT as a non invasive method with high accuracy and sensitivity can provide an excellent predictor of the risk of vertebral compressive fracture. The BMD of 10mm midplane measurement with QCT is extremely sensitive for predicting VCS and should be extensively studied in clinical practices.
出处
《中国医学影像技术》
CSCD
2002年第7期625-627,共3页
Chinese Journal of Medical Imaging Technology
