摘要
目的 :观察低分子量肝素 (LMWH)对不稳定型心绞痛 (UA)患者血浆内皮素 (ET)、一氧化氮(NO)水平的影响 ,探讨LMWH治疗UA的机理。方法 :UA患者在常规治疗基础上腹部皮下注射低分子量肝素 75 0 0IU ,12h 1次。用放射免疫法及化学比色法分别测定其血浆ET、NO水平。结果 :UA患者血浆ET水平明显高于对照组 (P <0 .0 1) ,NO水平明显低于对照组 (P <0 .0 1) ,经LMWH治疗后ET水平由治疗前(91.4 2± 2 6 .12 )ng/L下降至 (6 7.2 8± 17.94 )ng/L(P <0 .0 1) ,NO水平由治疗前 (37.89± 9.2 3) μmol/L升高至 (48.5 6± 11.74 ) μmol/L(P <0 .0 1) ,治疗前、后ET与NO水平均有显著性差异 ;治疗后与对照组相比ET、NO水平均差异无统计学意义。结论 :LMWH可改善血管内皮功能 ,使ET合成下降、NO合成增加 ;通过扩张血管、抑制血小板聚集。
Objective: To observe the effect of low molecular weight heparin(LMWH) on plasmic endothelin (ET) and nitric oxide (NO) level in unstable angine (UA) patients and to study the mechanism of LMWH in treating UA. Methods: On the basis of conventional treatment, unstable angina patients were injected hypodermically 7500IU LMWH, q12 h. Plasmic ET and NO were determined respectively with radioimmunoassay and chemical colorimetry before and after therapy. Results: The plasmic ET level of UA patients was markedly higher than that of the control group (P<0.01), and the NO level was much lower (P<0.01). Through LMWH treatment the ET level decreased from (91.42±26.12)ng/L to (67.28±17.94)ng/L (P<0.01) and the NO level increased from (37.89±9.23)μmol/L to (48.56±11.74) μmol/L(P<0.01).There were significant differente in both levels of ET and NO before and after LMWH treatment, but after LMWH treatment there was no statistical difference between UA group and the normal control group. Conclusion: The study indicates that LMWH can better the function of vessel endothelium to lower the level of ET and increase NO synthesis.Therefore the mechanisms of LMWH in treatment of UA can be attributed to dilating blood vessels,inhibiting aggregation of platelets and resisting thrombosis.
出处
《山东大学学报（医学版）》
CAS
2002年第3期247-249,共3页
Journal of Shandong University:Health Sciences
