摘要
泛素 -蛋白酶体降解途径在多种蛋白浓度的调节中发挥重要作用。泛素连接酶家族的一个成员SCF复合物 (Skp1- Cul1- F -box蛋白 )通过降解多个细胞周期调节蛋白促使细胞进入增殖周期。本文综述了SCF复合物的组成和结构以及这一复合物对细胞周期调控因子的调节作用。
Targeted protein degradation by the ubiquitin-proteasome pathway plays a vital role in monitoring the abundance of many short-lived regulatory proteins. SCF (Skp1-Cul1-F-box protein) complex, as a kind of ubiquitin ligase, drives the cell division cycle by the timely destruction of numerous regulatory proteins. This review describes the composition and structure of SCF complex and its function in cell cycle.\;
出处
《中国生物工程杂志》
CAS
CSCD
2002年第3期1-3,共3页
China Biotechnology
