摘要
目的 :研究老年 2型糖尿病患者凝血指标的变化 ,及其与血管并发症的关系。方法 :选取病史 5年以上老年 2型糖尿病患者 75例 ,其中血糖控制良好、无血管并发症组 3 1例 (男 18,女 13 ) ,血糖控制不佳、有血管并发症组 44例 (男 2 7,女 17) ;相应年龄健康对照人群 3 0例 (男、女各 15例 )。分别测定血浆凝血酶原时间 (PT)、活化部分凝血酶原时间 (APTT)、凝血酶时间 (TT)、纤维蛋白原 (Fg)、空腹血糖 (Glu)、糖化血红蛋白 (HbA1c)水平。结果 :无论有无血管并发症 ,老年 2型糖尿病患者的血浆Fg水平均较健康对照组升高 ,有血管并发症组Fg水平高于无并发症组 ,且同组内女性患者Fg水平高于男性 ;老年 2型糖尿病组PT、APTT较对照组缩短 ,且有并发症组PT、APTT低于无并发症组 ;上述参数的变化与空腹血糖或糖化血红蛋白水平无关。结论 :老年 2型糖尿病患者存在凝血功能的紊乱 ,凝血功能紊乱是患者血管并发症的重要因素 ,并且可能是导致女性患者较男性患者有较高的血管病变风险的因素之一。
Objective: To investigate the changes of plasma coagulation parameters in aged NIDDM patients, and the relationship of plasma coagulation parameters with angiopathy.Methods: Plasma prothrombin time(PT), activated partial thromboplastin time(APTT),fibrinogen(Fg), thrombin time(TT),glucose(GLU) and glycosylated hemoglobin(HbA 1C ) were determined in 31 NIDDM patients, whom were diagnosed more than five years ago and have had no complications. Forty four NIDDM patients have micro or macroangiopathy and 30 are controls. Results: Compared with the control group,NIDDM patients showed significantly shorter PT?APTT (male)and elevated Fg and these changes have independent relationship with serum GLU or HbA 1C .Whereas female diabetic patients showed significantly shorter APTT and elevated Fg. Furthermore, in NIDDM patients, those with micro or macroangiopathy showed shorter APTT?PT and higher Fg than those with no complications.Conclusions: Our study showed that NIDDM patients had coagulation activation, and that female diabetic patients seemed to constitute a higher risk group for micro or macroangiopathy than males.
出处
《江苏大学学报（医学版）》
CAS
2002年第3期252-253,共2页
Journal of Jiangsu University：Medicine Edition
