摘要
目的 提高异位促肾上腺皮质激素综合征 (异位ACTH综合征 )诊断和治疗效果。方法 回顾分析 1985年 7月～ 1999年 7月收治的 12例异位ACTH综合征患者的临床表现、诊断和治疗的临床资料。 结果 12例患者经内分泌检查诊断为异位ACTH综合症 ,10例经影像学检查发现原发肿瘤。随访 7个月～ 8年 ,5例手术切除肿瘤者 ,3例死亡 ;3例肾上腺切除者 ,1例存活至今 ;4例化疗者均死亡。 结论 对有库欣综合征症状的患者 ,先经内分泌检查确诊为异位ACTH综合征 ,结合原发肿瘤的症状和体征 ,对好发肿瘤的部位进行影像学筛查 ,有助于发现原发肿瘤。对原发肿瘤进行根治性切除 ,预后较好。
Objectives To increase the diagnosis and treatment of ectopic ACTH syndrome. Methods The data of 12 ectopic ACTH syndrome patients treated from 1985 to 1999 were retrospectively analyzed. Results Twelve patients were diagnosed as having ACTH syndrome by endocrinary test and primary tumors were ascertained by imaging examination. Follow up from 7 months to 8 years showed 3 out of 5 patients with radical resection of primary tumor died. One patient with bilateral adrenorectomy was still alive. All patients received only chemotherapy except one died. Conclusions Patients with Cushing′s syndrome should be evaluated by endocrine test and followed up by imaging screen examination. The key points to increase treatment effect include early detection, localization and resection of primary tumors.
出处
《中华外科杂志》
CAS
CSCD
北大核心
2002年第7期525-527,共3页
Chinese Journal of Surgery
