摘要
目的 探讨不同化疗药物经动脉及静脉途径注射后血浆及组织内药物浓度的变化规律。方法 10只成年新西兰雌兔随机平均分为两组 (动脉组和静脉组 )。一组经髂内动脉、另一组经耳缘静脉注射顺铂 (DDP)、5 氟脲嘧啶 (5 Fu)和依托泊甙 (Vp 16 )。注射后于不同时间采血样及子宫组织标本 ,以HPLC法测定血浆及子宫组织中药物浓度。所得数据用 3P97软件处理 ,计算药代动力学参数。结果 动脉及静脉注射 3种药物后 ,在血浆及靶组织中的浓度均呈现了规律性的变化 ,其变化过程均可以两室模型来描述。动脉注射 3种药物的药代动力学参数与静脉注射的药代动力学参数不同 ,动脉组注射药物后 ,血浆药物峰浓度均低于静脉组 ,而靶组织内药物峰浓度均高于静脉组 ,靶组织内药物AUC(药时曲线下面积 )值均明显高于静脉组。结论 动脉注射DDP、5 Fu和Vp 16较静脉注射有不同程度的优势 。
Objective To study the concentration change of chemotherapeutic agents in plasma and tissu e after intraarterial and intravenous injection. Methods Ten mature female New Zealand rabbits were divided randomly into two groups. Fl uorouracil, etopiside, and cisplatin were injected into the rabbits through the ear vein in one group and through the internal iliac artery in the other group. Blood samples and the uterus tissue specimens were collected at various time poi nt s after injection. Drug concentration in plasma and tissue was determined by hig h performance liquid chromatography (HPLC) method. The data were analyzed by the pharmacokinetic program 3P97. Results Regular concentration change of the three drugs in plasma and tissue was observe d after the intravenous and intraarterial injection, which met the two-compartme nt model. The pharmacokinetic parameters of the three drugs after intravenous an d intraarterial injection were different. The peak concentration in plasma after intraaterial injection was lower than that after intravenous injection and the peak concentration and area under curve (AUC) value in tissue after intra arterial injections were higher than those after intravenous injection. Conclusion Intraarterial chemotherapy has advantages to intravenous chemotherapy in fluorou racil, etopiside and cisplatin. These advantages depend on the drug pharmacolog ical properties.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2002年第4期344-347,共4页
Chinese Journal of Oncology
