摘要
目的 探讨结直肠癌肝转移的相关因素。方法 收集结直肠癌病例 1312例 ,建立数据库。选择性别、年龄、血型、病程、首发症状、肿瘤大小、组织类型、肠壁侵袭、淋巴结转移等临床因素 ,用Logistic回归 (spss10 .0统计软件 )进行单因素和多因素分析。并对有意义的指标进行相关分析。结果 单因素分析显示 ,性别、病程、肿瘤大体类型、组织类型、病理分级、肠壁侵袭和淋巴结转移与肝转移有关。多因素分析显示 ,仅性别、肠壁侵袭和淋巴结转移与肝转移有关。结直肠癌肝转移男女性别比为 1.9∶1。肝转移发生与肿瘤侵袭肠壁的层次呈正相关 (r=0 .92 6 ,P =0 .0 2 4 )。肝转移发生与淋巴结转移距离的远近无关 (r =0 .74 8,P =0 .2 5 2 )。结论 结直肠癌肝转移的相关因素主要有性别、肿瘤侵袭深度和淋巴结转移。男性结直肠癌患者更易发生肝转移。肿瘤侵袭肠壁越深 ,发生肝转移的危险越大。年龄、血型、病程、首发症状、肿瘤部位、肿瘤大小、术前合并症。
Objective To investigate the clinical factors related with liver metastasis from colorecta l cancer. Methods 1 312 colorectal cancer patients treated from 1988 to 1997 were collected to set up the database. Binary and multinomial logistic regression (SPSS 10.0 for windo ws) and then correlation analysis were used to evaluate the factors concerned. Results Sex, disease course, gross tumor type, differentiation degree, pathological gr ade, infiltration depth and lymph node metastasis were related with liver meta stasis by single factor analysis. Only sex, infiltration depth and lymph node me tastasis were related with liver metastasis by multiple factor analysis. More m ale than female were observed in patients with liver metastasis from colorectal cancer ( 1.9∶1 , P =0.006). Liver metastasis in colorectal cancer was posi tive ly related to the infiltration depth into the intestine wall( r =0.926, P = 0.024 ). However, the correlation between the distance of lymph node metastasis and l iver metastasis in colorectal cancer had no statistical significance( r =0.74 8, P =0.252). Conclusion Sex, depth of infiltration and lymph node metastasis are the main clinical facto rs related with liver metastasis from colorectal cancer. Male colorectal cancer patients are apt to develop liver metastasis. The deeper the tumor infiltrates, the more the liver metastasis. Age, blood type, symptoms, course, complications, tumor size and site are not related with liver metastasis in colorecta l carcinoma.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2002年第4期367-369,共3页
Chinese Journal of Oncology
关键词
结直肠癌
肝转移
危险因素
LOGISTIC回归分析
Colorectal neoplasms
Liver neoplasms/secondary
Lymphatic metastasis
Factor analysis, statistical
