摘要
背景与目的:阿霉素(ADM)、氮烯咪氨(DTIC)、异环磷酰胺(IFO)为治疗进展期软组织肉瘤常用的化疗药物,但对ADM或常规剂量的IFO治疗失效的软组织肉瘤再化疗的有效方案甚少。本文探讨大剂量IFO治疗常规方案失效的软组织肉瘤的疗效及不良反应。方法:对15例常规ADM及IFO治疗失效的软组织肉瘤患者(10例进展期,5例术后化疗)采用IFO总量14g/m2持续静滴6天治疗。结果:进展期10例患者CR2例,PR2例,总有效率40%。随访4～48个月,中位生存期(21.00±3.29)个月,中位缓解时间(6.00±1.45)个月。主要不良反应为骨髓抑制,Ⅲ～Ⅳ度中性粒细胞减少占45.9%。结论:大剂量IFO治疗软组织肉瘤有效率较高,为常规ADM及IFO治疗失效后较好的挽救治疗方法。
Background &Objective:Adriamycin,dacarbazine and ifosfa mide are three effective chemothera py drugs in treating progressive soft tissue sarcoma.However,few regimen is eff ective for the patients who failed in treatment with prior Adriamycin and ifosfamide at s tandard dose.This study was designed to observe and evaluate the efficac y and toxicity of high dose ifosfamide(HDI )regimen on pre-treated soft tissue s arcoma.Methods:Ten patients with advanced soft tiss ue sarcoma and 5patients after surgica l resection were treated with HDI adm inistered by continuous infusion at a dose of 14g /m 2 per cycle over 6days.All patients we re pretreated with anthracycline +/-standard dose ifosfamide.Results:An overall response rate of 40%was obse rved with 2complete and 2partial rem ission.In the follow up at 4-48month,the overall median survival time was 21±3.29months and the median response d uration was 6±1.45months.The major toxicity was myelosuppression.45.9%patients experienced grade 3-4neutropenia.Conclusion:HDI is an active salvage regimen in anthracycline +/-standard dose ifosfamide pretreated soft t issue sarcoma.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2002年第8期903-906,共4页
Chinese Journal of Cancer
