摘要
大鼠皮下注射异丙肾上腺素(40mg/kg/日)造成心肌损伤模型,发现心肌组织钙含量和心肌AGTⅡ水平显著增加,并伴有严重的心肌损伤。若同时注射牛磺酸(200mg/kg/日)或疏甲丙辅酸(1mg/kg/日)均可拮抗异丙肾上腺素引起的心肌钙增加及AGTⅡ水平升高,并可缓解心肌组织病理损伤。结果提示牛磺酸抑制心肌AGTⅡ可能是其拮抗异丙肾上腺素心肌损伤的重要机制之一。
On the model of myocardial damage induced by subcutaneous injection of isoproterenol (40mg/kg, twice) into rats, it was found that the myocardial calcium content and the level of myocardial angiotensin Ⅱ (AGT Ⅱ,ir) were significantly elevated, and that severe myocardial ischemic lesion occurred. The treatment with taurine (200mg/kg, twice) or captopril(1mg/kg, twice)antigonized the above effects of isoprotercnol dramatically and ameliorated the myocardial damage. The results suggest that taurine has inhibitary action on synthesis of heart AGT Ⅱ, and that this is one of the important mechanisms by which taurine protects heart from isoproterenol-induced myocardial injury.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1991年第6期566-568,共3页
Chinese Journal of Pathophysiology
