摘要
采用共表面活性剂法合成了孔道结构高度有序、孔径较大且粒径均匀的 SBA-1 5颗粒 ,并在此基础上研究了其作为毛细管液相色谱柱的填料基体的特性 .在 SBA-1 5材料上进行 C1 8官能团化前后 ,分别对 4种巯基化合物即半胱氨酸、谷胱甘肽、多巴胺和
C 18 functionalized mesoporous silica SBA 15 with a high surface area was applied in high performance liquid chromatography(HPLC) to separate small biomolecules: cysteine, glutathione, dopamine and 6 thiopurine. Compared to commercial available C 18 column, C 18 SBA 15 has a much higher surface area, which enhances the capillary HPLC resolution by increasing molecular capacity factors. The uniform distributed mesopores in SBA 15 result in HPLC peaks narrower than that of commercial column. Mesoporous SBA 15 can be used as an excellent HPLC stationary phase for special applications for its low cost, easy synthesis and various group modifications.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2002年第8期1494-1497,共4页
Chemical Journal of Chinese Universities
基金
国家重点基础研究专项经费 (批准号 :2 0 0 1CB5 10 2 0 2 )
复旦大学 Bio-X/Med-X基金资助
