摘要
目的探讨开搏通与洛沙坦合用对冠心病患者血管内皮功能和可溶性细胞间粘附分子 -1(s ICAM-1)的影响。方法用放免方法和酶联免疫吸附法测定了内皮素 -1(ET-1)、一氧化氮 (NO)和 s ICAM-1的变化。结果应用开搏通和洛沙坦的患者 ET-1和 s ICAM-1明显降低 ;NO,尤其是 NO/ ET-1比值明显升高 ,与对照组相比 ,有显著性差异。
Objective To explore the effect of captopril and losartan on the blood vessel endothelial function and soluble intercellular adhesion molecule 1 (sICAM 1) in coronary heart disease patients. Methods Nitric oxide (NO),endothelin 1 (ET 1) and sICAM 1 were determined by means of radioimmunosorbent and enzyme linked immunosorbent assay. Results ET 1 and sICAM 1 were obviously lowered,while NO,especially NO/ET 1 was remarkably higher in the patients using captopril and losartan than controls,with significant differences. Conclusion The combination of captopril and losartan has protective effect on the blood vessel endothelial function in coronary heart disease patients
出处
《中国综合临床》
北大核心
2002年第8期688-689,共2页
Clinical Medicine of China
