摘要
目的 探讨腹腔镜联合妈富隆、孕三烯酮及亮丙瑞林治疗子宫内膜异位症的临床效果.方法 收集50例因子宫内膜异位症行腹腔镜手术的患者,并以数字法随机分为观察组和对照组,各25例.对照组予腹腔镜手术治疗,观察组予腹腔镜手术联合妈富隆、孕三烯酮及亮丙瑞林治疗,疗程为3个月,观察比较2组临床疗效,复发率、妊娠率及术后恢复情况.结果 治疗后有效率观察组为92.0％（23/25）,对照组为64.0％（16/25）,差异有统计学意义（P＜0.05）.治疗后复发率观察组为8.0％ （2/25）,对照组为32.0％（8/25）,差异有统计学意义（P＜0.05）.治疗后妊娠率观察组为80.0％,对照组为48.0％,差异有统计学意义（P＜0.05）.治疗后2组均未出现肝功能损害等不良反应.观察组下床活动时间为（1.4±0.4）d,住院时间为（7.6±3.5）d;对照组下床活动时间为（3.6±1.5）d,住院时间为（11.5±3.9）d,差异有统计学意义（P＜0.05）.结论 腹腔镜手术联合妈富隆、孕三烯酮及亮丙瑞林治疗子宫内膜异位症临床疗效明显优于单纯手术组,能提高有效率和妊娠率,降低复发率,未发现明显不良反应,值得临床推广.
Objective To explore the clinical effects of laparoscopic surgery combined with marvelon,gestrinone and leuprolide in treatment of chronic endometriosis.Methods 50 cases of endometriosis were collected.They were randomly divided into observation group and control group,each group having 25 cases.The control group underwent laparoscopic surgery and the observation group underwent laparoscopic surgery combined marvelon,gestrinone and leuprolide for 3 months.The two groups were compared in clinical effects,recurrence and pregnancy rate,as well as the operation situation.Results The effective rate was 92.0％ （23/25） in the observation group and 64.0％ （16/25） in the control group.The effective rate of observation group was obviously higher than that of the control group（P ＜ 0.05）.The recurrence rate was 8.0％ （2/25）in the observation group,and 32.0％ （8/25） in the control group.The recurrence rate of combination group was obviously lower than that of the simple surgical group（P ＜ 0.05）.The pregnancy rate was 80.0％ in the observation group;and 48.0％ in the control group after treatment.The pregnancy rate of the observation group was obviously higher than that of the control group（P ＜ 0.05）.Liver damage or other adverse reactions didn＇t occur to any group after the treatment.The mean time of leaving bed was （1.4 ± 0.4） d after operation in the observation group vs （3.6 ± 1.5） d after operation in the control group.Length of hospital stay was （7.6 ± 3.5） d in the observation group vs （11.5 ± 3.9） d in the control group.The difference had statistical significance（all P ＜ 0.05）.Conclusions Laparoscopic surgery combined with marvelon,gestrinone and leuprolide is superior to pure surgery group in treatment of endometriosis.It can improve the effective and pregnancy rate,and reduce the recurrence rate.No obvious adverse reactions can be found,thus it is worth of clinical promotion.
出处
《中华内分泌外科杂志》
CAS
2014年第3期200-202,共3页
Chinese Journal of Endocrine Surgery
