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ICU患者应用右美托咪啶与咪达唑仑镇静后谵妄发生率的比较 被引量:15

Comparison of delirium incidence rate between dexmedetomodine and midazolam in ICU patients
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摘要 目的比较重症医学科(ICU)患者采用右美托咪定与咪达唑仑镇静所致谵妄的发生率。方法 2013年4~11月我科收治的40例患者,按照随机数字表法分为右美托咪定组和咪达唑仑组各20例,分别给予右美托咪定和咪达唑仑镇静,比较两组谵妄的发生率。结果两组镇静起效时间差异无统计学意义(P〉0.05)。镇静过程中,右美托咪定谵妄发生率低于咪达唑仑组(P〈0.05)。结论 ICU谵妄是一组常见的监护病房临床综合征,使用右美托咪啶镇静谵妄的发生率较低。 Objective To compare the delirium incidence rate induced by dexmedetomodine with that by midazolam in sedative patients of ICU.Methods Forty sedative patients in ICU from Apr.2013 to Nov.2013 were randomly divided into two groups.The delirium incidence rate was compared between the two groups.Results There was no significant difference in gender proportion,age and onset time of sedation between the two groups.The delirium incidence rate in the dexmedetomodine group was significant lower than that in the midazolam group(P〈0.05).Conclusion Delirium is a common set of ICU clinical syndrome.The incidence rate of dexmedetomodine was significant lower than that of midazolam.
出处 《实用医院临床杂志》 2014年第4期223-224,共2页 Practical Journal of Clinical Medicine
关键词 右美托咪定 咪达唑仑 ICU 镇静 谵妄 Dexmedetomodine Midazolam ICU Sedation Delirium
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  • 1Jacobi J,Fraser GL,Coursin DB,et al.Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult.Crit Care Med,2002,30:119-141.
  • 2Ostermann ME,Keenan SP,Seiferling RA,et al.Sedation in the intensive care unit:a systematic review.JAMA,2000,283:1451-1459.
  • 3Hayaahi Y,Maze M.Alpha2 adrenoceptor agonists and anaesthesia.Br J Anaesth,1993,71:108-118.
  • 4Khan ZP,Ferguson CN,Jones RM.Alpha-2 and imidazoline receptor agonists,their pharmacology and therapeutic role.Anaesthesia,1999,54:146-165.
  • 5Bhana N,Goa KL,McClellan KJ.Dexmedetomidine.Drugs,2000,59:263-268.
  • 6Maze M,Scarfini C,Cavaliere F.New agents for sedation in the intensive care unit.Crit Care Clin,2001,17:881-897.
  • 7Venn RM,Bryant A,Hall GM,et al.Effects of dexmedetomidine on adrenocortical function,and the cardiovascular,endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit.Br J Anaesth,2001,86:650-656.
  • 8Herr DL,Sum-Ping ST,England M.ICU sedation after coronary artery bypass graft surgery:dexmedetomidine-based versus propofol-based sedation regimens.J Cardiothorac Vasc Anesth,2003,17:576-584.
  • 9Venn RM,Grounds RM.Comparison between dexmedetomidine and propofol for sedation in the intensive care unit:patient and clinician perceptions.Br J Anaesth,2001,87:684-690.
  • 10Martin E,Ramsay G,Mantz J,et al.The role of the alpha2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit.J Intensive Care Med,2003,18:29-41.

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  • 1李民,张利萍,吴新民.右美托咪啶在临床麻醉中应用的研究进展[J].中国临床药理学杂志,2007,23(6):466-470. 被引量:483
  • 2田斌斌,仲华根,薛润喜,孙跃,张培红,韩进,王宏伟.咪唑安定顺行性遗忘作用在剖宫产手术中的临床观察[J].中国医药导刊,2013,15(S1):138-139. 被引量:3
  • 3肖少华.小剂量咪达唑仑用于围术期镇静[J].医学综述,2005,11(6):536-538. 被引量:15
  • 4袁力勇,戴体俊.认知功能障碍发病机制研究进展[J].现代生物医学进展,2007,7(1):126-130. 被引量:29
  • 5Girard TD,Jackson JC,Pandharipande PP,et al.Delirium as apredictor of long-term cognitive impairment in survivors ofcritical illness[J].Crit Care Med,2010,38(7): 1513-1520.
  • 6Barr J,Fraser GL,Puntillo K,et al.Clinical practice guide-lines for the management of pain,agitation,and deliriumin adult patients in the intensive care unit[J].Crit CareMed,2013,41(1):263-306.
  • 7Patel RP,Gambrell M,Speroff T,et al.Delirium and seda-tion in the intensive care unit : survey of behaviors and at-titudes of 1384 healthcare professionals [J]. Crit Care Med,2009,37(3):825-832.
  • 8Page VJ.Tackling agitated delirium-the tip of the ice-berg[J].Crit Care,2009,13(3) : 158.
  • 9Young J,Murthy L,Westby M,et al.Diagnosis,prevention,and management of delirium : summary of NICE guidance[J].BMJ, 2010,341 :c3704.
  • 10Marcantonio E,Ta T,Duthie E,et al.Delirium severity andpsychomotor types:their relationship with outcomes after hipfracture repair[J].J Am Geriatr Soc, 2002,50(5): 850-857.

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