摘要
目的研究产妇高危型人乳头状瘤病毒(HPV)感染的状况,找出其感染的影响因素,为预防宫颈癌提供有效途径。方法选用2010年8月-2012年10月在医院生产的产妇857例作为观察组,选用同一时间在医院进行宫颈癌筛查的2473例产妇作为对照组,根据40、130、220、310d4个时间点留取产妇宫颈样本,采用第二代杂交捕获(HC-Ⅱ)检测技术进行高危型人乳头状瘤病毒(HR-HPV)检测;比较观察组与对照组产妇的HR-HPV感染情况。结果产后40dHR-HPV感染产妇的感染率观察组为10.39%、对照组为10.55%,两组差异无统计学意义;产后40、130、220、310d4个时间点的HR-HPV感染患者感染率分别为10.23%、13.55%、8.41%和8.88%,产后130d的感染率明显高于其他3个时间点,其间差异有统计学意义(P<0.05)。结论不良性生活习惯是HR-HPV感染的重要途径,产后一年内有针对性的对文化程度低、农村的产妇进行HR-HPV感染筛查,对降低这类人群的宫颈癌病发率有重要的临床意义。
OBJECTIVE To investigate the prevalence of high-risk human papillomavirus （HPV） infections among the postpartum women and observe the influencing factors for the infection so as to effectively prevent cervical cancer. METHODS A total of 857 pregnant women who gave birth in the hospital from Aug 2010 to Oct 2012 were selected as the observation group, meanwhile, 2473 pregnant women who underwent the cervical cancer screening in the hospital were set as the control group, the cervical specimens were sampled at four time points （on day 40, 130, 220, 310, respectively）, the high-risk HPV was tested by using the second generation of hybrid capture （HC-II）, and the incidence of high-risk HPV infection was compared between the observation group and the con- trol group. RESULTS After giving birth for 40 days, the incidence of high-risk HPV infection was 10.39% in the observation group, 10.55 % in the control group, there was no significant difference between the two groups; the incidence rate of high-risk HPV infection was 10. 23% on day 40, 13. 55% on day 130, 8. 41% on day 220, 8.88% on day 310, the infection rate was significantly higher on day 130 than on other three time points, there was significant between-group difference （P〈0.05）. CONCLUSION Bad habit is a leading cause for the high-risk HPV infection, and it is of great Significance to conduct the high-risk HPV infection screening for the pregnant women from rural area who have low level of education and give birth within one year so as to reduce the incidence of cervical cancer among the population.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第13期3330-3332,共3页
Chinese Journal of Nosocomiology
基金
浙江省舟山市医药卫生科技基金项目(2010A07)
关键词
产妇
高危型
人乳头状瘤病毒
宫颈癌
Postpartum woman
High-risk
Human papillomavirus
Cervical cancer
