摘要
目的:研究疫肠内营养对于慢阻肺合并Ⅱ型呼吸衰竭患者免疫恢复情况的影响。方法:选取2011年6月-2013年1月在我院进行住院治疗的90例慢阻肺合并Ⅱ型呼吸衰竭患者,按随机分组原则将其分为实验组和对照组,实验组患者给予免疫肠内营养支持治疗,对照组患者进行常规肠内营养支持,分别在方案实施前、实施后2天、9天测量患者血浆蛋白(前白蛋白、白蛋白、转铁蛋白),外周血淋巴细胞亚群(CD3+,CD8+,CD4+/CD8+)、血清免疫球蛋白(IgA,IgG,IgM)、IL-2和IL-6的浓度水平,通过实验组、对照组、正常值之间的比较进行效果评价。结果:两组患者在进行营养支持疗法前,以上数值无明显差异,实施后第2天,两组患者血浆蛋白含量、血淋巴细胞亚群(CD3+,CD4+/CD8+)、血清免疫球蛋白(IgA,IgG,IgM)、IL-2的浓度明显提升,但实验组患者的免疫相关数值和对照组无明显差异,P>0.05,差异无统计学意义;第9天时,两组患者,两组患者外周血淋巴细胞亚群(CD3+,CD4+/CD8+)、血清免疫球蛋白(IgA,IgG,IgM)、IL-2在明显提升的基础上,实验组明显高于对照组,但仍低于正常值,P<0.05,差异有统计学意义。但CD8+、IL-6出现明显下降,实验组明显低于对照组,P<0.05,差异有统计学意义。结论:免疫肠内营养能够有效改善机体营养状态,增强机体免疫功能,促进患者恢复,建议在临床上推广应用。
Objective： To study the impact of immune enteral nutrition on the immune recovery of patients with copd combined type Ⅱ respiratory failure. Methods： Between June 2011 and January 2013, 90 patients with copd combined Ⅱ type of respiratory failure were hospitalized in our hospital for treatment. They were divided according to the principle of random grouping into the experimental group and the control group. Patients in experimental group were given immune enteral nutrition support treatment, and patients in control group were given conventional enteral nutrition support. We detected the levels of plasma proteins（prealbumin, albumin and transferrin）, peripheral blood lymphocyte subsets（CD3＋, CD8＋, CD4＋/CD8＋）, serum immunoglobulin（IgA, IgG, IgM） and concentrations of IL-2 and IL-6, respectively at before treatment, 2 d after treatment, 9 d after treatment. Compare them between experimental group,control group and normal group. Results： Before undergoing nutrition support therapy, the above mentioned value had no difference between the two groups. After 2 days, the levels of plasma protein, blood lymphocyte subsets（CD3＋, CD4＋/CD8＋）, serum immunoglobulin（IgA, IgG, IgM） and IL-2 raised significantly in two groups. But the immune-related values had no obvious difference between the two groups（P〉0.05）. At the 9d after treatment, the levels of blood lymphocyte subsets（CD3＋, CD4＋/CD8＋）, serum immunoglobulin（IgA, IgG, IgM） and IL-2 raised significantly in both groups but still below the normal value, and they raised greater in experimental group than in control group, and differences had statistical significance（P〈0.05）. However, the levels of CD8＋and IL-6declined significantly, and were significantly lower in experimental group than in control group, and the difference was statistically significant（P〈0.05）. Conclusion： The immune enteral nutrition can effectively improve the body＇s nutritional status, enhance the body＇s immune function, and promote recovery of patient. It could be recommended in clinical application.
出处
《现代生物医学进展》
CAS
2014年第23期4522-4525,共4页
Progress in Modern Biomedicine
关键词
免疫肠内营养
慢阻肺合并Ⅱ型呼吸衰竭
免疫恢复
Immune enteral nutrition
Copd combined type Ⅱ respiratory failure
Immune recovery
