摘要
目的 探讨生长激素（GH）、瘦素、甲状腺激素在胎儿生长发育中的作用.方法 选取新生儿120例（男婴60例,女婴60例）,根据新生儿出生体质量与胎龄的关系分为适于胎龄儿（AGA）、大于胎龄儿（LAG）和小于胎龄儿（SGA）三组,分别测定三组胎儿出生时的头围、身长、体质量、体质量指数、双顶径、胎盘重量及生长激素、瘦素、甲状腺激素的含量.结果 三组新生儿出生时生长发育的6个指标差异均有统计学意义.与AGA组相比,SGA组新生儿脐血GH和促甲状腺激素（TSH）均明显升高[（21.52±2.13）ng/L比（15.64±1.28） ng/L,（8.6±0.67） mIU/L比（3.34±0.29） mIU/L,t=3.042,、4.367,均P＜0.05],瘦素、T3和T4均明显降低[（7.53±0.81） μg/L比（9.55±1.26） μg/L,（1.25±0.42） nmol/L比（1.48±0.37） nmol/L,（69.45±10.07） nmol/L比（76.68±8.22） nmol/L,t=1.749、1.905、1.783,均P＜0.05].LGA组新生儿瘦素明显高于AGA组新生儿[（14.61±2.05） μg/L比（9.55±1.26） μg/L,t=3.064,P＜0.05].且瘦素和T3、T4与生长发育指标头围、身长、体质量、体质量指数、双顶径及胎盘重量呈正相关（均P＜0.05）,TSH与头围、身长、体质量、体质量指数、双顶径及胎盘重量呈负相关（P＞0.05）.结论 瘦素、甲状腺激素水平与胎儿生长发育均有密切关系,可作为胎儿宫内生长发育的一个客观指标,对评估胎儿生长发育具有重要的临床意义.
Objective To explore the role of growth hormone （GH）,leptin （Lep）,T3,T4,TSH in cord blood in intrauterine growth.Methods 120 healthy newborns （60 males,60 females） were enrolled in this study.The neonates were divided into AGA,LGA and SGA groups according to the relationship between birth weight and gestation.The head circumference,birth length,birth weight,body mass index,biparietal diameter,and placental weight,the levels of GH,Lep,T3,T4,TSH in the cord blood were measured.Results There were significantly statistical differ ences in growth indexs （all P 〈 0.05）,the levels of GH and TSH were significantly increased [（21.52 ± 2.13） ng/L vs （15.64 ± 1.28） ng/L ; （8.6 ± 0.67） mIU/L vs （3.34 ± 0.29） mIU/L,t =3.042,4.367,all P 〈 0.05] and Lep,T3,T4 were significantly decreased in LGA group when compared with the AGA group [（7.53 ±0.81） g/L vs （9.55 ± 1.26） g/L; （1.25 ± 0.42） nmol/L vs （1.48 ± 0.37） nmol/L; （69.45 ± 10.07） nmol/L vs （76.68 ± 8.22） nmol/L; t =1.749,1.905,1.783,all P 〈 0.05],the level of Lep in LGA group was significantly higer than that in AGA group [（14.61 ±2.05） g/L vs （9.55 ±1.26） g/L,t =3.064,P 〈0.05].And GH,Lep,T3,T4 were positively correlated with head circumference,birth length,birth weight,body mass index,biparietal diameter,and placental weight （all P 〈 0.05）.TSH was negatively correlated with growth indexs.Conclusion The levels of Lep,T3,T4,TSH in cord blood were associated with fetal growth and could be used as indicators of intrauterine growth.
出处
《中国基层医药》
CAS
2014年第13期1969-1971,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
生长激素
瘦素
甲状腺激素类
儿童发育
婴儿
新生
胎血
Growth hormone
Leptin
Thyroid hormones
Child development
Infant, newborn
Fetal blood
