摘要
目的：了解妊娠年龄对妊娠及分娩结局的影响。方法收集北京、上海、江苏、陕西、四川、辽宁及广东等14个省市自治区共39家医院，2011年妊娠满28周至足月住院分娩的孕产妇病历资料，共110450例。以孕产妇年龄5岁间隔分成6组。以25～29岁组为参考组，应用二元Logistic回归分析计算其他年龄组的相对危险度（OR）。结果孕产妇的平均分娩年龄（28±5）岁。35～39岁组及≥40岁组妊娠合并糖尿病（35～39岁组及≥40岁组OR值分别为2.2和3.8）、妊娠合并慢性高血压（OR值4.6和6.5）、妊娠合并子宫肌瘤（OR值4.2和5.8）、妊娠期糖尿病（OR值2.6和3.5）、子痫前期（OR值2.5和3.6）、产后出血（OR值1.5和1.7）、早产（OR值1.8和2.4）、前置胎盘（OR值2.7和4.0）、胎盘早剥（OR值1.4和2.5）、剖宫产分娩（OR值2.1和2.5）、巨大儿（OR值1.2和1.2）、低出生体重儿（OR值1.6和2.3）及围产儿死亡（OR值1.6和3.7）的发生风险均高于参考组。＜20岁的低龄组与参考组比较，妊娠合并贫血（ OR值1.4）、子痫前期（ OR值1.6）、早产（OR值2.1）、低出生体重儿（OR值2.3）及围产儿死亡（OR值3.6）的发生风险增加。结论20～30岁为妊娠及分娩的最适年龄，高龄孕妇及低龄孕妇的母婴风险均增加。
Objective To determine the pregnancy outcomes related with maternal age in China . Methods A total of 110 450 cases were selected and divided into 6 age groups at intervals of 5 years.The clinical data were collected from 39 hospitals in China's Mainland.All deliveries were after 28 weeks of completed gestation in 2011.The unadjusted binary-logistic regression was employed for statistics .Results The mean age of all pregnant women was 28 ±5 at the time of delivery.The advanced age groups （35-39 yr and ≥40 yr） had higher risks than the 25-29 age group for pregestational diabetes [ odds ratio （ OR） , 2.2 and 3.8], chronic hypertension （OR, 4.6 and 6.5）, leiomyoma （OR, 4.2 and 5.8）, gestational diabetes （ OR, 2.6 and 3.5 ） , preeclampsia （ OR, 2.5 and 3.6 ） , postpartum hemorrhage （ OR, 1.5 and 1.7 ） , premature delivery （OR, 1.8 and 2.4）, placenta previa （OR, 2.7 and 4.0）, placental abruption （OR, 1.4 and 2.5）, cesarean delivery （OR, 2.1 and 2.5）, macrosomia （OR, 1.2 and 1.2）, low birth weight neonates （OR, 1.6 and 2.3） and perinatal mortality （OR, 1.6 and 3.7）.The adolescent group had higher risks than the 25-29 age group for anemia （OR, 1.4）, preeclampsia （OR, 1.6）, preterm birth （OR, 2.1）, low birth weight neonates （OR, 2.3） and perinatal mortality （OR, 3.6）.Conclusion Maternal and neonatal risks are higher during both the adolescent and advanced maternal ages .And the age group of 20-30 years has the lowest risk for pregnancy and delivery .
出处
《中华医学杂志》
CAS
CSCD
北大核心
2014年第25期1984-1988,共5页
National Medical Journal of China
基金
卫生部公益项目基金（201002013）
关键词
高龄孕妇
低龄孕妇
妊娠结局
新生儿结局
Advanced maternal age
Adolescent pregnancy
Pregnancy outcome
Neonatal outcom
