摘要
目的探讨血管内皮生长因子-C(VEGF-C)及血管内皮细胞生长因子受体-3(VEGFR-3)的表达与结肠癌淋巴结转移的关系。方法收集经病理证实的结肠癌手术标本45例(研究组,淋巴结转移23例,未转移22例)和同期良性结肠黏膜息肉标本20例(对照组)。均采用免疫组织化学SP法检测结肠癌组织及良性结肠黏膜息肉组织中VEGF-C及VEGFR-3的表达水平,分析VEGF-C、VEGFR-3表达与淋巴结转移的关系。结果研究组VEGF-C阳性率及VEGFR-3表达均高于对照组(均P<0.01)。淋巴结转移组的VEGF-C阳性率及VEGFR-3阳性表达(LVD)均明显高于淋巴结未转移组[(91.3%比40.9%),(21.07±5.14比10.56±5.01),均P<0.01]。结论结肠癌存在VEGF-C及VEGFR-3的高表达,可能与促进淋巴结转移有关。
Objective To explore the relationship between the expression of vascular endothelial growth factor C （VEGF-C）and vascular endothelial growth factor receptor-3 （VEGFR-3）and lymph node metastasis in colon carcinoma. Methods The levels of VEGF-C and VEGFR-3 expression were determined by immunohistochemistry in 45 pathology-confirmed colon cancer specimens （study group, 23 cases of lymph node metastasis and 22 cases of non- metastasis ）and 20 benign colonic mucosal polyp specimens（control group）.The relationship between the expression of VEGF-C and VEGFR-3 and lymph node metastasis was analyzed. Results Compared with control group, the positive rate of VEGF-C and the expression of VEGFR-3 significantly increased in study group （P〈0.01）.Compared with non-metastasis group, the positive rate of VEGF-C and the expression of VEGFR-3 significantly increased in lymph node metastasis group（91.3% vs 40.9% and 21.07±5.14 vs 10.56±5.01, respectiv-ely;P〈0.01）. Conclusion The VEGF-C and VEGFR-3 are highly expressed in colon carci-noma, and the expression of VEGF-C and VEGFR-3 may promote lymph node metastasis.
出处
《实用临床医学（江西）》
CAS
2014年第4期32-34,F0003,共4页
Practical Clinical Medicine
关键词
结肠癌
血管内皮生长因子-C
血管内皮细胞生长因子受体-3
淋巴结转移
colon carcinoma
vascular endothelial growth factor-C
vascular endothelial growth factor receptor-3
lymph node metastasis
