期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Clusterin在卵巢癌中的研究进展 被引量：1

Progression of clusterin in ovarian cancer
下载PDF
导出
摘要 丛生蛋白(Clusterin,CLU)是一种广泛存在于各种组织中并表达的糖蛋白,参与多种生理病理过程。丛生蛋白(CLU)在肿瘤发生发展过程中起重要作用。在卵巢癌的研究中,CLU也被认为与其发生发展及预后有着密切的联系,CLU的高表达可能与卵巢癌的预后不良有关。CLU也被认为与增加卵巢癌对紫杉醇的耐药有关,因此针对Clusterin基因的分子靶向治疗可以增加对紫杉醇类抗癌药物的敏感性。本文就CLU在卵巢癌中的研究进展作一综述。 Clusterin （CLU） is an enigmatic glycoprotein with ubiquitous tissue distribution, and involved in many biological processes and pathological states. Clusterin plays an important role in the process of cancer. In ovarian cancer, GLU was reported to correlate with the tumorigenesis and progression. The high expression of GLU may be related to the poor prognosis of ovarian cancer in survival analysis. CLU is also thought to associated with drug resistance of paeli- taxel in ovarian cancer, thus molecular targeted therapy for Clusterin gene can increase the sensitivity of paclitaxel.
作者 徐宁 赵霞
机构地区 四川大学华西第二医院妇产科
出处 《西部医学》 2014年第7期959-960,F0003,共3页 Medical Journal of West China
基金 国家自然科学基金(81372246)
关键词 CLUSTERIN 卵巢癌 预后 化学治疗 靶向治疗 Clusterin Ovarian cancer Prognosis Chemotherapy Targeted therapy
分类号 R737.31 [医药卫生—肿瘤]
  • 相关文献

参考文献23

  • 1Goff BA, Sainz CR, Muntz HG* et al. Clear cell carcinoma ofthe ovaryt a distinct histologic type with poor prognosis and re-sistance to platinum-based chemotherapy in stage III disease[J]. Gynecol Oncol, 1996, 60:412-417.
  • 2Whitehouse C, Solomon E. Current status of the molecularcharacterization of the ovarian cancer antigen CA125 and implica-tions for its use in clinical screening [J]. Gynecol Oncol,2003,88(12):152-157.
  • 3Fritz IB,Burdzy K,SetcheUB,et al. Ram rete testis fluid con-tains a protein (clusterin) which influences cell-cell interactionsin vitro[J]. Biol Report, 1983, 28:1173-1188.
  • 4Rizzi F . Bettuzzi S. The clusterin paradigm in prostate andbreast carcinogenesis[J], Endocr Relat Cancer, 2010,17(1):1-17.
  • 5Fink TM, Zimmer M, Tschopp J, et al. Human clusterin(CLU) maps to 8p21 in proximity to the lipoprotein lipase(LPL) gene [J]. Genomics* 1993,16:526-528.
  • 6Leskov KS,Klokov DY, Li J. etal. Synthesis and functional a-nalysis of nuclear clusterin , a cell death protein [J], J BiolChem, 2003, 278: 11590-11600.
  • 7Caccamo AE. Scaltriti M, Caporali A, et al. Ca2+ depletion in-duces nuclear clusterin ,a novel effector of apoptosis in immor-talized human prostate cells [J]. Cell Death Differ, 2005, 12:101-104.
  • 8Bettuzzi S . Introduction [J], Adv Cancer Res, 20091 104:1-8.
  • 9Trougakos IP, Gonos ES. Clusterin/ apolipoprotein in humanaging and cancer [ J] . Int J Biochem. Cell Biol, 2002, 34( 11):1430-1448.
  • 10Trougakos IP, So A, Jansen B, et al. Silencing expression of the clusterin/apolipoprotein gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress[J]. Cancer Res, 2004, 64(5),1834-1842.

二级参考文献48

  • 1杨国奋,李晓明,谢丹,朝葵,蔡鹏宇.卵巢癌组织中clusterin蛋白表达和细胞凋亡检测[J].中国肿瘤临床,2007,34(12):674-676. 被引量：17
  • 2Garrctt SC, Hodgson L, Rybin A, et al. A biosensor of S100A4 metastasis factor activation: inhibitor screening and cellular activation dynamics [ J ]. Biochemistry, 2008, 22,47:986-96.
  • 3Kikuchi N, Horiuchi A, Osada R,et al. Nuclear expression of S100A4 is associated with aggressive behavior of epithelial ovarian carcinoma: an important autocrine/paracrine factor in tumor progression [ J ]. Cancer Sci, 2006, 97: 1061-1069.
  • 4Maelandsmo GM, Florenes VA, Nguyen MT, et al. Different expression and clinical role of S100A4 in serous ovarian carcinoma at different anatomic sites [ J ]. Tumour Biol, 2009,30 : 15-25.
  • 5Gilks CB, Vanderhyden BC, Zhu S, et al. Distinction between serous tumors of low malignant potential and serous carcinomas based on global mRNA expression profiling [ J ]. Gynecol Oncol,2005,96:684-694.
  • 6Yang GF,Li XM,Xie D. Overexpression of clusterin in ovarian cancer is correlated with impaired survival[ J]. Int J Gynecol Cancer,2009,19 : 1342-1346.
  • 7Shannan B, Seifert M, Leskov K, Willis J, Boothman D, Tilgen W,et al. Challenge and promise: roles for clusterin in pathogen esis,progression and therapy of eancer[J]. Cell Death Differ, 2006,13:12-19.
  • 8Zhang H,Kim J K,Edwards C A,Xu Z,Taichman R,Wang C Y. Clusterin inhibits apoptosis by interacting with activated Bax [J]. Nat Cell Biol,2005,7:909- 915.
  • 9Xie D,Lau S H,Sham J S,Wu Q L,Fang Y,Liang L Z,et al. Up-regulated expression of cytoplasmic clusterin in human ovarian carcinoma[J]. Cancer, 2005,103 : 227-283.
  • 10July L V,Beraldi E,So A,Fazli L,Evans K,English J C,et al. Nucleotide-based therapies targeting clusterin ehemosensitize human lung adenocarcinoma cells both in vitro and in vivo[J]. Mol Cancer Ther, 2004,3 : 223-232.

共引文献9

同被引文献4

二级引证文献7

西部医学
2014年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部