摘要
目的系统评价Beclin1蛋白表达与宫颈癌及其不同临床病理特征的相关性。方法计算机检索h e Cochrane Library(2014年第1期)、PubMed、EMbase、Ovid、CNKI、VIP、CBM和WanFang Data,查找国内外公开发表关于Beclin1蛋白表达与宫颈癌及其不同临床病理特征相关性的病例-对照研究,检索时限均为从建库至2014年2月。由2位评价员按照纳入与排除标准独立筛选文献、提取资料和评价纳入研究的方法学质量后,采用RevMan 5.2软件进行Meta分析。结果最终纳入5个病例-对照研究,共计637例患者,包括宫颈癌组388例,宫颈上皮内瘤样病变(CIN)组130例,正常宫颈组织组119例。Meta分析结果显示:①Beclin1在宫颈癌组与正常宫颈组[OR=0.07,95%CI(0.02,0.25),P<0.000 1]、宫颈癌组与CIN组[OR=0.37,95%CI(0.23,0.59),P<0.000 1]、CIN组与正常宫颈组[OR=0.23,95%CI(0.06,0.88),P=0.003]的表达差异均有统计学意义。②Beclin1在宫颈癌伴淋巴结转移组与无淋巴结转移组[OR=0.29,95%CI(0.17,0.49),P<0.000 01]的表达差异有统计学意义;然而在宫颈癌中低分化组与高分化组[OR=0.50,95%CI(0.16,1.56),P=0.23]、宫颈癌肿瘤直径≥4 cm组与直径<4 cm组[OR=0.72,95%CI(0.44,1.18),P=0.20]、宫颈癌肌层浸润深度≥1/2组与浸润深度<1/2组[OR=0.76,95%CI(0.49,1.20),P=0.25]、宫颈癌FIGO临床分期Ⅱ期组与Ⅰ期组[OR=0.70,95%CI(0.44,1.10),P=0.12]的表达差异均无统计学意义。结论 Beclin1蛋白的表达与宫颈癌有显著相关性。受纳入研究数量和质量限制,上述结论尚待开展更多高质量研究加以验证。
Objective To systematically review the correlation between Beclinl protein expression and cervical cancer as well as its different clinical pathologic features. Methods We electronically searched databases including The Cochrane Library （Issue 1, 2014）, PubMed, EMbase, Ovid, CNKI, VIP, CBM and WanFang Data from inception to Feb- ruary 2014, to collect the correlation between Beclinl protein expression and cervical cancer as well as its different clinical pathologic features. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assessed the methodological quality of the included studies. Then meta-analysis was conducted us- ing RevMan 5.2 software. Results A total of 5 case-control studies involving 637 patients were included, of which, 388 cases in the cervical cancer group, 130 cases in the cervical intraepithelial neoplasia （CIN） group, and 119 cases in the normal cervical tissue group. The results ofmeta-analysis showed that, a） as for Beclinl expression, significant differences were found in cervical cancer vs. normal cervical tissues （OR=0.07, 95%CI 0.02 to 0.25, P〈0.000 1）, cervical cancer vs. CIN （OR=0.37, 95%CI 0.23 to 0.59, P〈0.000 1）, CIN vs. normal cervical tissues （OR=0.23, 95%CI 0.06 to 0.88, P=0.03）, and cervical cancer tissues with vs. without lymph node metastasis （OR=0.29, 95%CI 0.17 to 0.49, P〈0.000 01）. However, no significant difference was found in medium/low differentiation vs. well differentiation （OR=0.50, 95%CI 0.16 to 1.56, P=0.23）, tumour diameter no less than vs. less than 4 cm （OR=0.72, 95%CI 0.44 to 1.18, P=0.20）, myometrial invasion depth no less than vs. less than 1/2, and FIGO I vs. II （OR=0.70, 95%CI 0.44 to 1.10, P=0.12）. Condusion Beclinl pro- tein expression is notably associated to cervical cancer. Due to the limited quantity and quality of the included studies, the above conclusion still needs to be further verified by performing more high quality studies.
出处
《中国循证医学杂志》
CSCD
2014年第7期798-805,共8页
Chinese Journal of Evidence-based Medicine
基金
山西省科技攻关项目(编号:20120313019-2)
山西省卫生厅攻关项目(编号:2011024)
