摘要
目的系统评价转载蛋白E(ApoE)基因多态性与中国人群散发型阿尔茨海默病(SAD)的相关性。方法计算机检索PubMed、EMbase、CBM、h e Cochrane Library(2013年第8期)、CNKI、VIP和WanFang Data,查找国内外关于ApoE基因多态性与中国人群SAD相关性的病例-对照研究,检索时限均为从建库至2013年8月。由2位评价员按照纳入与排除标准独立筛选文献、提取资料和评价纳入研究的方法学质量后,采用Stata12.0软件进行Meta分析。结果最终纳入50个病例-对照研究,共计病例3 396例,对照4 917例。Meta分析结果显示:对于中国人群,等位基因ε4人群的SAD发病风险是等位基因ε3人群2.89倍[OR=2.89,95%CI(2.61,3.19),P<0.001];基因型ε4/ε4人群的SAD发病风险是基因型ε3/ε3人群7.24倍[OR=7.24,95%CI(5.11,10.24),P<0.001];基因型ε3/ε4人群的SAD发病风险是基因型ε3/ε3人群2.90倍[OR=2.90,95%CI(2.56,3.29),P<0.001];基因型ε2/ε4人群的SAD发病风险是基因型ε3/ε3人群2.11倍[OR=2.11,95%CI(1.64,2.72),P<0.001];而基因型ε2/ε3、ε2/ε2及等位基因ε2人群与基因型ε3/ε3、等位基因ε3人群的SAD发病风险无明显差异。结论对于中国人群,ApoE等位基因ε4与SAD发病有关,且基因型ε4/ε4是SAD的高危因素;等位基因ε2与SAD发病无相关性。鉴于现有大量研究均未行分层分析,今后尚需针对SAD临床分型及患者特征等因素进一步展开相关研究。
Objective To systematically review the correlation between apolipoprotein E （ApoE） polymorphism and sporadic Alzheimer＇s disease （SAD） in Chinese population. Methods The case-control studies about the relation- ship between ApoE polymorphism and SAD in Chinese population were electronically retrieved in PubMed, EMbase, CBM, The Cochrane Library （Issue 8, 2013）, CNKI, VIP, and WanFang Data from the date of their establishment to August 2013. Literature screening according to the inclusion and exclusion criteria, data extraction and methodological quality assessment of the included stuides were completed by two reviewers independently. Meta-analysis was then con- ducted using Stata 12.0 software. Results A total of 50 case-control studies invovling 3 396 cases and 4 917 controls were finally included. The results of meta-analysis showed that, in Chinese, the risk of SAD was 2.89 times higher in population with allele e4 than in population with allele e3 （OR=2.89, 95%CI 2.61 to 3.19, P〈0.001）; 7.24 times higher in those with e4/e4 genotype than in those with e3/e3 genotype （OR=7.24, 95%CI 5.11 to 10.24, P〈0.001）; 2.90 times higher in e3/e4 genotype than in e3/e3 genotype （OR=2.90, 95%CI 2.56 to 3.29, P〈0.001）; 2.11 times higher in ~2/e4 genotype than in e3/ e3 genotype （OR=2.11, 95%CI 1.64 to 2.72, P〈0.001）; and no statistic significance was found in the risk of SAD compared e2/e3, e2/e2 genotypes and e2 allele with e3/e3 genotype and e3 allele. Conclusion For Chinese population, ApoE allele e4 is significantly associated with the onset of SAD, and genotype E4/e4 is a high risk factor of SAD. While allele e2 is not associated with the onset of SAD. Since a great deal of current studies failed to conduct stratified analysis, it is suggested to further conduct relevant relevant studies according to clinical classification of SAD and patients＇ characteristics.
出处
《中国循证医学杂志》
CSCD
2014年第7期813-820,共8页
Chinese Journal of Evidence-based Medicine
基金
十堰市太和医院2014年循证医学"苗圃基金"项目(编号:EBM2014009)
