摘要
目的探讨左卡尼汀联合百令胶囊对腹膜透析患者微炎症状态、残余肾功能及营养状况的影响。方法选择在我科进行腹膜透析治疗的慢性肾衰竭患者56例为研究对象,随机分为观察组和对照组,每组28例。对照组在常规腹膜透析及基础治疗的同时给予左卡尼汀治疗,观察组在左卡尼汀治疗基础上加用百令胶囊治疗。观察并记录两组患者治疗前及治疗6个月后相关指标变化情况。结果两组患者治疗6个月后,BUN、Scr水平均较治疗前有所降低,差异均无统计学意义(P>0.05)。两组患者Ccr水平均较治疗前有所升高,但差异无统计学意义(P>0.05)。两组CRP、IL-6、TNF-α均较治疗前明显改善,差异有统计学意义(P<0.05或P<0.01),且观察组改善更为明显(P<0.01)。两组Alb、PA、TRF、Hb水平均较治疗前升高,SGA评分降低,但观察组改善更为明显(P<0.05或P<0.01)。两组患者不良反应发生率差异无统计学意义(P>0.05)。结论左卡尼汀联合百令胶囊治疗较单独用药具有更好的临床疗效且具有良好的安全性。
Objective To investigate the effect on residual renal function,micro-inflammation state and nutritional status of peritoneal dialysis patients treating with levocarnitine combined with Bailing capsule.Methods 56 cases of chronic renal failure patients who were given peritoneal dialysis treatment in our department were randomly divided into observation group and control group,28 cases in each group,the control group was given routine peritoneal dialysis and basic treatment,at the same time was given levocarnitine treatment,the observation group was given Bailing capsule on the basis of control group.The related indicators of the two groups were observed and recorded.Results After 6 months treatment,the BUN,Scr level of the two groups were lower than those before treatment,the differences had no statistical significance（P〉0.05）.The Ccr level of the two groups was higher than that before treatment,the differences had no statistical significance（P〉0.05）.The CRP,IL-6,TNF level of the two groups were obviously improved,the difference had statistical significance（P〈0.05 or P〈0.01）,and the observation group improved more significantly（P〈0.01）.The Alb,PA,TRF,Hb level of the two groups were all higher than those befor treatment,SGA score reduced,but the observation group improved more significantly（P〈0.05 or P〈0.01）.The incidence of adverse reactions between the two groups had no statistical significance（P〉0.05）.Conclusion Peritoneal dialysis patients treating with levocarnitine combined with Bailing capsule can effectively improve the indicators and has good security than drug using alone.
出处
《实用药物与临床》
CAS
2014年第7期860-864,共5页
Practical Pharmacy and Clinical Remedies
关键词
左卡尼汀
百令胶囊
腹膜透析
微炎症
残余肾功能
营养
Levocarnitine
Bailing capsule
Peritoneal dialysis
Micro-inflammation
Residual renal function
Nutrition
