摘要
目的探讨不同时间使用氨甲环酸对初次行髋关节置换术患者失血量的影响。方法将90例初次行髋关节置换术的患者按随机数字表法分为:早期组(30例,氨甲环酸术前1 h使用)、晚期组(30例,氨甲环酸术中使用)和对照组(30例,不使用)。统计分析患者的显性红细胞丢失量、隐性红细胞丢失量与总红细胞丢失量。结果 (1)对照组(96.3±21.7)mL的显性失血量显著多于早期组(45.9±9.7)mL、晚期组(46.2±9.5)mL,Ps<0.01;早期组的显性失血量与晚期组差异无统计学意义(P>0.05)。(2)早期组(140.6±21.1)mL、晚期组(216.7±48.6)mL的隐性失血量显著少于对照组(335.1±60.3)mL,Ps<0.01;早期组的隐性失血量明显少于晚期组(P<0.01)。(3)早期组(236.7±42.4)mL、晚期组(344.0±51.5)mL的总红细胞丢失量显著少于对照组(492.8±65.1)mL,Ps<0.01;早期组的总红细胞丢失量明显少于晚期组(P<0.01)。结论氨甲环酸能够明显减少初次行髋关节置换术患者的失血量,术前1 h使用比术中使用更能明显减少隐性失血量。
Objective To discuss the impact of the application timing in tranexamic acid therapy on the blood loss of patients with preliminary total hip arthroplasty. Methods Ninety patients with preliminary total hip arthroplasty were assigned into early stage group（n= 30,tranexamic acid at preoperative one hour）,advanced stage group（n = 30,tranexamic acid in operation）,and control group（n =30,without tranexamic acid）. The visible red blood cell loss,hidden red blood cell loss,and total red blood cell loss were analyzed. Results（1） The visible red blood cell loss in control group（96. 3 ± 21. 7） mL was significantly more than early stage group（45. 9 ± 9.7） mL and advanced stage group（46. 2 ± 9. 5） mL,Ps 0. 01. There were no significant differences between early stage group and advanced stage group（P〈0. 05）.（2） The hidden red blood cell loss in early stage group（140. 6 ± 21. 1） mL and advanced stage group（216.7 ±48.6） mL were significantly lower than control group（335.1 ±60.3） mL,Ps 0.01. Moreover,hidden red blood cell loss in early stage group was significantly lower than advanced stage group（P〈0. 01）.（3） The total red blood cell loss in early stage group（236.7 ±42.4） mL and advanced stage group（344.0 ±51.5） mL were significantly lower than control group（492.8 ±65.1） mL,Ps 0. 01. The total red blood cell loss in early stage group was significantly lower than advanced stage group（P〈0. 01）. Conclusions Tranexamic acid reduces the blood loss in preliminary total hip arthroplasty,especially reducing hidden blood loss when used at preoperative one hour.
出处
《安徽医药》
CAS
2014年第8期1569-1571,共3页
Anhui Medical and Pharmaceutical Journal
关键词
髋关节置换术
氨甲环酸
失血量
total hip arthroplasty
tranexamic acid
blood loss
