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缩泉丸对老年大鼠尿动力学的影响 被引量:3

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摘要 目的:观察衰老所致的尿动力参数的变化,并观察缩泉丸对自然衰老大鼠尿动力的影响。方法:选择自然衰老的老年大鼠,随机分为老年模型组、缩泉丸组和托特罗定组,用正常3月龄大鼠做对照,给药6周,正常组与模型组给予同体积蒸馏水,末次给药后对各组大鼠进行尿动力学检测。结果:与正常组比较,自然衰老动物BLPP、ALPP、MVP、MUP、MUCP和EV明显降低,MBC、BC、PVR明显升高,(P〈0.05--0.01),缩泉丸显著升高BLPP、ALPP、EV、MVP、MUP和MUCP,降低BC和PVR的值,对MBC和FUL没有明显影响,托特罗定组显著升高BLPP、ALPP、MVP、EV、MBC、MUP和MUCP,降低MBC和PVR,对BC无明显影响(P〈0.05--0.01)。结论:衰老大鼠出现尿动力学异常改变,缩泉丸可以改善老年大鼠的尿动力学异常。
出处 《中医药临床杂志》 2014年第6期605-607,共3页 Clinical Journal of Traditional Chinese Medicine
基金 国家自然科学基金(项目编号81202982)
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