摘要
目的分析高病毒载量慢性丙型肝炎患者的流行病学特点、临床表现及生化特征等。方法对242例确诊为慢性丙型肝炎患者的临床资料进行回顾性分析,比较高病毒载量(HCV-RNA>4×105 IU/ml)和低病毒载量(HCVRNA≤4×105IU/ml)患者的流行病学特点、临床表现及生化、肝纤维化、快速病毒学应答率等特征。结果高病毒载量患者的临床表现、性别组成、年龄分布、感染途径与低病毒载量患者相似。高病毒载量患者的血脂(血清低密度脂蛋白胆固醇、甘油三酯)水平及快速病毒学应答率较低病毒载量患者低,差异均有统计学意义(P<0.05或P<0.01),两组患者的ALT、AST水平及基因型分布、肝硬化发生率、肝纤维化指标差异均无统计学意义(P>0.05)。结论高病毒载量患者与低病毒载量患者具有相似的流行病学特点,与低病毒载量患者相比,高病毒载量患者血脂(血清低密度脂蛋白胆固醇、甘油三酯)水平及获得快速病毒学应答率低。
Objective To analyze epidemiological, clinical and biochemical characteristics of patients with high viral load of chronic hepatitis C（CHC）. Methods The clinical data of 242 patients diagnosed with CHC were reviewed. High viral load patients（HCV-RNA〉4×10^5IU / ml） were compared in terms of epidemiological, clinical, biochemical characteristics and the rate of rapid virological response with low viral load patients（HCV-RNA≤4×10^5IU / ml）. Results The high viral load patients have similarities with low viral load patients in clinical manifestation, gender composition, age distribution, routes of infection. However,the level of blood lipid（serum low-density lipoprotein, glycerin triglyceride）and the rate of rapid virological response are significantly lower than those in low viral load patients（P〈 0.05 and P 〈0.01）,whereas there are no signifcant differences in the ALT,AST levels,genotype distribution,liver cirrhosis ratio,and hepatic fibrosis indexes between high and low viral load patients（P〉0.05）. Conclusion The high viral load patients have similarities with low viral load patients in epidemiological characteristics.Compared with low viral load patients,the level of blood lipid（serum low-density lipoprotein, glycerin triglyceride） and the rate of rapid virological response in high viral load patients are lower.
出处
《热带医学杂志》
CAS
2014年第6期741-744,共4页
Journal of Tropical Medicine
基金
广东省科技计划项目立项课题(2010B031600009)
关键词
慢性丙型肝炎
高病毒载量
流行特征
临床特点
chronic hepatitis C
high viral load
epidemiological characteristics
clinical features
