摘要
目的分析抑癌蛋白2(ST2)、超敏C反应蛋白(hs-CRP)、颈动脉内膜中层厚度(IMT)与颈动脉粥样硬化(AS)患者严重程度的相关性,比较重度粥样硬化组粥样硬化斑块性质对ST2、hs-CRP、IMT的影响。方法分别采用ELISA法和免疫比浊法检测117例颈动脉粥样硬化患者(轻、中、重度颈动脉粥样硬化患者分别为37例、31例、49例)和103名正常人血清ST2和hs-CRP含量,高分辨率超声观察IMT和判断粥样硬化斑块的性质。结果颈动脉粥样硬化患者的IMT(0.87±0.19)、ST2(1283.44±197.52)和hs-CRP(7.35±3.94)较正常对照组IMT(0.29±0.13)、ST2(692.68±175.84)和hs-CRP(2.64±2.05)明显升高,差异有统计学意义(P﹤0.01)。AS组重度和中度颈动脉粥样硬化患者与轻度颈动脉粥样硬化患者相比,IMT、ST2和hs-CRP水平明显增高,差异有统计学意义(P<0.01或P<0.05)。重度动脉粥样硬化的易损斑块患者与稳定斑块患者相比IMT、ST2和hs-CRP水平明显升高,差异有统计学意义(P<0.01)。相关分析显示,ST2和hs-CRP与IMT均呈正相关(r分别为0.295和0.363,P均<0.01)。结论高水平IMT、ST2和hs-CRP与颈动脉粥样硬化密切相关,可以预测重度动脉粥样硬化斑块的性质,判断颈动脉粥样硬化的严重程度。
Objective To analyze the correlation of suppression of tumorigenicity 2 （ST2）, high sensitive C reactive protein （hs-CRP）, intima media thickness （IMT）level and the severity of carotid atherosclerosis （AS）, and the effect of atheroselerotic plaques on the levels of ST2, hs-CRP and IMT. Methods ELISA and immune turbidimetry assay were used to determine the levels of serum ST2 and hs-CRP in 117 patients with carotid atherosclerosis （light, medium, severe carotid atherosclerosis patients were 37 cases, 31 cases, 49 cases, respectively） and 103 normal people. Carotid artery IMT and atherosclerosis plaque properties were evaluated by high resolution ultrasound. Results The results in patients with the levels of IMT（0.87±0.19）,ST2 （1283.44±197.52） and hs-CRP （7.35±3.94） of carotid atherosclerosis patients were significantly higher than those of normal people [IMT（0.29±0.13）, ST2（692.68±175.84）, hs-CRP（2.64± 2.05） ] ,P〈0.01. The levels of carotid artery IMT, ST2 and hs-CRP were significantly different among the severe, moderate and mild atherosclerosis patients （P〈0.01 or P〈0.05）.The levels of IMT,ST2 and hs-CRP of the severe atheroselerosis with vulnerable plaque were significantly higher than those with stable plaque （P〈0.01）. The levels of ST2 and high sensitive C reactive protein were positively correlated with the carotid artery intima-media thickness （r were 0.295 and 0.363, all P 〈0.01 ）. Conclusion The levels of IMT, ST2 and high sensitivity C reactive protein can be used to evaluate the nature of the atherosclerotic plaque and the severity of atherosclerosis.
出处
《热带医学杂志》
CAS
2014年第6期771-773,794,共4页
Journal of Tropical Medicine
