摘要
目的了解内蒙古鄂尔多斯市中心医院临床分离的肠球菌属细菌的分布情况及对各类抗菌药物的耐药性。方法使用VITEK2 compact全自动细菌检测分析系统对2010年1月至2013年6月从临床标本中分离的271株肠球菌属细菌进行菌种鉴定和药敏试验,并用WHONET5.6软件对结果进行统计分析。结果 271株肠球菌属细菌中,屎肠球菌137株(50.6%),粪肠球菌80株(29.5%),其他肠球菌54株(19.9%)。肠球菌属细菌主要分离自尿液69株(25.5%)、脓液40株(14.8%)、伤口等分泌物34株(12.5%)。粪肠球菌对万古霉素和利奈唑胺的耐药率分别为1.3%和1.5%;未检出呋喃妥因耐药株;对青霉素和氨苄西林的耐药率较低,分别为11.8%和2.6%;对高浓度庆大霉素和高浓度链霉素的耐药率分别为31.0%和22.9%。屎肠球菌的耐药率明显高于粪肠球菌,对万古霉素的耐药率为4.4%,未检出利奈唑胺耐药株,对呋喃妥因的耐药率为19.1%;对高浓度庆大霉素和高浓度链霉素的耐药率分别为44.8%和26.4%;但对四环素和奎奴普丁-达福普汀的耐药率低于粪肠球菌,分别为58.3%和0。结论屎肠球菌对抗菌药物的耐药率较粪肠球菌高;并已出现对万古霉素耐药株;其耐药性存在地区和菌种间差异,临床治疗应根据细菌药敏结果合理选用抗菌药物。
Objective To investigate the distribution and antimicrobial resistance in Enterococcus species isolated from Ordos Central Hospital. Methods The Enterococcus strains were isolated from clinical specimens from January 2010 to June 2013. The identification and antimicrobial susceptibility testing were completed on VITEK 2 Compact. WHONET 5.6 software was used to analyze the data. Results A total of 271 strains of Enterococcus were collected, including E. faecium （50.6%, 137/271）, E. faecalis （29.5 %, 80/271）, and other Enterococcus （19.9%, 54/271）. The Enterococcus isolates were mainly from urine （25.5%, 69/271）, pus （14. 8%, 40/271） and wound secretion （12. 5%, 34/271）. The E. faecalis strains were highly susceptible to vancomycin and linezolid. Only 1. 3% and 1. 5% of the strains were resistant to vancomycin and linezolid, respectively. No strains of E, faecalis were resistant to nitrofurantoin. The percentage of E. faecalis resistant to penicillin and ampicillin was 11. 8% and 2. 6%, respectively. About 31. 0% and 22. 9% of E. faecalis strains were resistant to gentamicin （high level） and streptomycin （high level）, respectively. The E. faecium strains were more resistant to most antibiotics tested than E. faecalis. The drug-resistance rate of E. faecium strains to vancomycin was 4.4%. But no strains were found resistant to linezolid. Only 19.1% of these strains were resistant to nitrofurantoin. Also 44.8% and 26.4% of E. faecium isolates were resistant to gentamicin （high level） and streptomycin （high level）, respectively. However, E. faeciurn was less resistant to tetracycline and quinupristin-dalfopristin than E. faecalis. The resistance rate was 58. 3% and 0, respectively. Conclusions The E. faeciurn strains are more resistant to most drugs tested than E. faecalis. Some strains are resistant to vancomycin. The resistance of Enterococcus varies widely with region and species. Antimicrobial therapy for such enterococcal infections should be based on the results of antimicrobial susceptibility testing.
出处
《中国感染与化疗杂志》
CAS
北大核心
2014年第4期323-326,共4页
Chinese Journal of Infection and Chemotherapy
基金
内蒙古自然科学基金(2013MS1116)
关键词
肠球菌属
抗生素
耐药性
Enterococcus
antibiotic
resistance
