摘要
目的探讨甲状腺球蛋白(TG)、抗甲状腺球蛋白抗体(A-TG)在分化型甲状腺癌(DTC)患者131I治疗后疗效评价中的应用价值。方法选取2008年1月至2013年2月间收治的106例DTC患者,按照TG水平将106例DTC患者分为TG阳性组(20例,TG≥30ng/ml)和TG阴性组(86例,TG<30ng/ml),另选35例健康人作为对照组,治疗前、治疗后2个月及6个月时测定血清TG和A-TG水平。结果 TG阴性组患者在治疗后2个月时TG水平为(13.51±3.81)ng/ml,显著低于治疗前(P<0.05)。TG阳性组患者治疗后2个月时TG水平为(70.17±5.71)ng/ml,显著低于治疗前(P<0.05),TG阴性组差异有统计学意义(P<0.05)。TG阴性组患者治疗2个月后A-TG升高者占19.8%,6个月后升高者占17.9%;TG阳性组患者治疗2个月后A-TG升高者占40.0%,6个月后升高者占30.0%,两组间差异均有统计学意义(P<0.05)。远处转移者患者TG水平升高者占58.3%,显著高于颈部转移者(34.6%),差异有统计学意义(P<0.05)。结论 TG有助于对手术切除甲状腺后行131I清甲治疗或转移灶治疗后患者病情的判断,但是无法避免A-TG对TG的干扰,因此临床需要同时检测患者血清A-TG水平,以便更加准确地判断患者疗效及预后。
Objective To study the thyroid globulin （ TG）, anti thyroglobulin antibodies （A-TG） application value in the evaluation of patients with postoperation 131I treatment of differentiated thyroid carci- noma. Methods 106 cases of DTC patients treated by 131 I thyroid radioiodine therapy or metastasis therapy after excision operation from 2008 January to 2013 February were divided into TG-negative group and TG- positive group, and 35 healthy people were selected as the control group. Serum A-TG and TG levels were determined and compared before,2 and 6 months after treatment. Results In both TG-negative group and TG-positive group, after 2 month -treatment and 6 month-treatment, the TG level of DTC patients were all significantly lower than that of the group before treatment （ P 〈 0. 05 ） ; A-TG positive rate were significantly decreased from 19. 8% to 17.9%, 40. 0% to 30% respectively （ P 〈 0. 05 ）. Distant metastasis rate was 58. 3%, which was significantly higher than that of neck metastasis （34. 6%, P 〈 0. 05 ）. Conclusion TG are helpful for effect judgment of patients with postoperation 131 Itreatment of differentiated thyroid carcino- ma, but cannot avoid the interference of A-TG. Serum A-TG level should be detected simultaneously in clinic to provide more accurate judgment and prognosis.
出处
《中国肿瘤临床与康复》
2014年第7期804-806,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
