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PI3K/AKT信号通路与恶性胶质母细胞瘤侵袭性 被引量:3

Recent advance in PI3K/AKT signaling pathway and invasiveness of malignant glioblastoma
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摘要 源自神经上皮的肿瘤统称为脑胶质瘤,占颅脑肿瘤的40%~50%,是最常见的颅内恶性肿瘤。根据病理可分为星形细胞瘤、髓母细胞瘤、多形胶母细胞瘤、室管膜瘤和少枝胶母细胞瘤等。多形性胶质母细胞瘤(GBM)是致死性最高的肿瘤之一。也是成年人中最常见的脑肿瘤.占颅内肿瘤的12%~15%和星形胶质细胞瘤的50%~60%,在大多数欧洲和北美洲国家中,每年新增病例为2~3人/10万;在全身肿瘤中GBM的5年死亡率仅次于胰腺癌和肺癌,居第3位,5年生存率不足5%。
出处 《中华神经医学杂志》 CAS CSCD 北大核心 2014年第7期667-671,共5页 Chinese Journal of Neuromedicine
关键词 恶性胶质母细胞瘤 磷脂酰肌醇3激酶 蛋白激酶B信号通路 侵袭性 Malignant glioblastoma Phosphatidylinositol 3 kinase/protein kinase B signalingpathway Invasion
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