摘要
目的研究N-末端脑钠肽前体(NT-proBNP)、D-二聚体浓度对老年社区获得性肺炎(CAP)的严重程度评估和结果预测。方法对180例老年CAP患者评估临床变量和肺炎严重指数(PSI),同时检测患者D-二聚体和NT-proBNP。按照PSI评分分组,比较各组NT-proBNP、D-二聚体的浓度,评价这些指标与CAP严重程度的关系。结果各组NT-proBNP、D-二聚体随着老年CAP严重程度升高而升高(P<0.01)。与PSI评分组合,NT-proBNP浓度随着病情严重程度的升高而升高。结论 NT-proBNP、D-二聚体可作为老年CAP患者严重程度分层较为有效的标志物。
Objective To evaluate the prediction and evaluation of N-terminal pro brain natriuretie peptide （NT-proBNP） and D-Dimer levels upon the severity of community-acquired pneumonia （CAP） in senile individuals. Methods Clinical variables and pneumonia severity index （PSI） of 180 elderly patients with CAP were evaluated and NT-proBNP and D-Dimer levels were measured simultaneously. All patients were divided into different groups according to PSI score. The levels of NT-proBNP and D-Dimer were statistically compared among all groups to evaluate the relationship between these indexes and the severity of CAP. Results NT-proBNP and D-Dimer levels were significantly increased with the severity of CAP in each group （P 〈 0. 01 ）. Combined with PSI, the level of NT-proBNP was elevated over the severity of this disease. Conclusion NT-proBNP and D-Dimer can be used as effective markers for stratification of the severity of CAP in elderly patients.
出处
《新医学》
2014年第7期452-454,共3页
Journal of New Medicine
关键词
社区获得性肺炎
肺炎严重指数
N-末端脑钠肽前体
D-二聚体
Community-acquired pneumonia
Pneumonia severity index
N- terminal pro-brain natriuretic peptide
D-Dimer
