摘要
目的 探讨血浆D-二聚体（DD）含量检测对肺栓塞（PE）的诊断价值.方法 69例第一诊断为肺栓塞的患者,测定入院时第一次采血的D-二聚体,其中D-二聚体阴性9例,阳性60例,对D-二聚体阴性及阳性的两组患者进行临床资料对比观察.结果 9例D-二聚体阴性肺栓塞患者的D-二聚体含量为（0.9±0.4）μg/ml,阴性率为13％（9/69）;D-二聚体阳性肺栓塞患者的D-二聚体含量为（16.5±14.2）μg/ml,阳性率为87％（60/69）.D-二聚体阴性与阳性两组之间在D-二聚体含量、发病时间及血栓栓塞部位等方面比较差异有统计学意义（P＜0.01）;而性别、年龄、肺动脉压、下肢静脉曲张及血栓形成等各指标比较差异无统计学意义（P＞0.05）.结论 血浆D-二聚体阴性并非100％排除肺栓塞,临床对高度怀疑肺栓塞的患者,不要只关注D-二聚体水平,还要进行肺动脉相关检查.
Objective The aim of this study was to re-evaluate the clinical diagnostic value of plasma D-dimer in pulmonary embolism（PE）.Methods We conducted a study of 69 consecutive patients diagnosed with PE between August 2011 and January 2014.The patients were divided into 2 groups：D-dimer negative PE（n=9） and D-dimer positive PE（n=60）.And the clinical data were collected for further analysis.Results D-dimer plasma levels were significantly lower in D-dimer negative PE patients compared with D-dimer positive PE patients （0.9±0.4）μg/ml vs （16.5±14.2）μg/ml.Significant difference in D-dimer levels,time of onset and thromboembolism parts were revealed between the two groups （P＜0.01）.And D-dimer of negative and positive two groups of patients with pulmonary embolism by gender,age,pulmonary artery pressure,lower extremity varicose veins and thrombosis and so on each index contrast have no difference （P＞0.05）.Conclusion It was difficult to exclude pulmonary embolism simply depending on the negative D-dimer levels.For patient who was highly suspected with pulmonary embolism,the level of D-dimer should not just focued on only,the related pulmonary artery inspection should be carried out.
出处
《中国心血管病研究》
CAS
2014年第7期598-600,共3页
Chinese Journal of Cardiovascular Research
关键词
D-二聚体
阴性
肺栓塞
D-dimer
Negative
Pulmonary embolism
