摘要
目的了解成都大学附属医院近3年铜绿假单胞菌的分布及对各种抗菌药物的耐药性,为临床合理使用抗生素提供指导。方法回顾性分析2011年1月至2013年12月住院患者送检标本所分离的铜绿假单胞菌的耐药率,使用WHONET 5.5软件进行耐药性分析。结果分离的2162株铜绿假单胞菌中有1583株来自呼吸道,占73.22%;主要分布在ICU、呼吸内科,分别占27.80%和20.58%;铜绿假单胞菌对头孢噻肟和头孢曲松耐药率最高,分别为67.30%和62.12%;对头孢哌酮/舒巴坦耐药率最低,为18.59%。对碳青霉烯类亚胺培南耐药率为32.10%,其中292株为多药耐药铜绿假单胞菌(MDRPA),检出率为13.51%,119株为泛耐药铜绿假单胞菌,检出率为5.50%。结论铜绿假单胞菌感染以ICU和呼吸内科为主,应对铜绿假单胞菌的耐药性进行重点监测,以便更好地控制铜绿假单胞菌的感染,为临床合理使用抗菌药物提供科学依据。
Objective To investigate the distribution and drug resistance of Pseudomonas aeruginosa in our hospital during past three years and provide evidence for the rational use of antibiotics. Methods A total of 2162 strains of P. aeruginosa were isolated from the specimens of patients hospitalized in our hospital from January 2011 to December2013,and their drug resistance was analyzed retrospectively by using WHONET 5. 5 software. Results Of 2162 strains of P. Aeruginosa,1583（73. 22%） were isolated from respiratory tract samples. The strains mainly detected from the patients in ICU（27. 80%） and respiratory disease department（20. 58%）. The isolated strains showed the high drug resistant rate to cefotaxime（67. 30%） and ceftriaxone（62. 12%） and the low drug resistant rate to cefoperazone /sulbactam. The drug resistance rates to imipenem was 32. 10%. The detection rate of multi drug resistant P. Aeruginosa and extensive drug resistant P. Aeruginosa were 13. 51% and 5. 50% respectively. Conclusion P. aeruginosa infection mainly occurred in the patients in ICU and respiratory disease department,and the monitoring of drug resistance of P. aeruginosa should be strengthened to control P. Aeruginosa infection and guide the rational use of antibiotics.
出处
《疾病监测》
CAS
2014年第6期454-457,共4页
Disease Surveillance
关键词
铜绿假单胞菌
抗菌药物
临床分布
耐药性
Pseudomonas aeruginosa
Antibiotic
Clinical distribution
Drug resistance
