摘要
目的观察角膜溃疡清创、碘酊烧灼联合那他霉素滴眼液和氟康唑滴眼液点眼治疗真菌性角膜溃疡的效果。方法收集真菌性角膜溃疡病人180例,将病人按治疗方法分为A组(75例)、B组(70例)及C组(35例)。所有病人均先行角膜溃疡清创、碘酊烧灼,然后A组采用那他霉素滴眼液和氟康唑滴眼液联合点眼,B组采用那他霉素滴眼液点眼,C组采用氟康唑滴眼液点眼。比较3组病人治愈率、治愈病例的治愈时间和视力变化。结果 A、B组的治愈率高于C组,差异有统计学意义(χ2=9.444、6.285,P<0.05);3组治愈病例的治愈时间分别为(25±4)、(26±5)、(30±12)d,差异无统计学意义(P>0.05);治愈病人视力有不同程度提高。结论角膜溃疡清创、碘酊烧灼联合那他霉素滴眼液及氟康唑滴眼液点眼是治疗真菌性角膜溃疡的一种非常有效的方法。
Objective To assess the effectiveness of combined therapy for fungal corneal ulcer（FCU）using corneal ulcer debridement,iodine tincture cautery,natamycin and fluconazole eye drops. Methods This study collected data of 180patients with FCU,who were divided into group A（n=75）,group B（n=70）and group C（n=35）according to their therapies.All patients were first treated with corneal ulcer debridement and iodine tincture cautery.The patients in the three groups were then treated separately as follows：group A,natamycin and fluconazole eye drops were applied;group B,used only natamycin eye drops;group C,applying fluconazole eye drops only.The cure rate,time spent for curative patients,and vision were compared between the three groups. Results The cure rate of groups A and B was higher than that of group C（χ2=9.444,6.285;P〈0.05）.The time spent in cured patients in groups A,B and C was（25±4）,（26±5）and（30±12）days,respectively,the difference between them was not statistically significant（P〈0.05）.The vision of the cured patients was improved to different extents. Conclusion The therapy of combined corneal ulcer debridement,iodine tincture cautery,natamycin and fluconazole eye drops is very effective for fungal corneal ulcer.
出处
《青岛大学医学院学报》
CAS
2014年第4期345-347,349,共4页
Acta Academiae Medicinae Qingdao Universitatis
